О роли киназ гликогенсинтазы в молекулярных механизмах стрессовых состояний и перспективах применения аскорбата лития

Общеизвестно, что комплекс нервных и гормональных сигналов при стрессе стимулирует секрецию адреналина, норадреналина и кортизола надпочечниками. Гораздо меньше внимания уделяется ролям промежуточных сигнальных белков, опосредующих эффекты «гормонов стресса», нейротрансмиттеров и других сигнальных молекул. В настоящей работе представлены результаты систематизации исследований киназ гликогенсинтазы GSK-3α и GSK-3β, избыточная активность которых усугубляет течение хронического стресса, оказывает негативное влияние на выживание нейронов и на процессы адаптации. Ионы лития являются естественным, природным ингибитором избыточной активности обеих GSK-3, что отчасти обусловливает нормотимический и антидепрессантный эффекты литиевых препаратов. Прием солей лития на основе органических анионов являются наиболее безопасным и эффективным способом восполнения дефицита лития в организме. Рассмотрены перспективы применения аскорбата лития для повышения адаптационных резервов организма. 

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