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A single unprovoked generalized seizure: Results of examination and 5-year follow-up in 47 patients

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Background. To choose tactics for patients with a single unprovoked generalized convulsive seizure (SUGCS) is a quite a challenge due to the lack of common approaches to interpreting this episode. Objective: to study the clinical, electroencephalographic (EEG), neuroimaging (magnetic resonance imaging (MRI) — positron emission tomography (PET)) and morphocytochemical features of peripheral blood cells (PBC) in patients with SUGCS. Patients and methods. Group 1 included 47 patients with SUGCS. A comparison group comprised 50 patients with different forms of locally induced symptomatic and/or cryptogenic epilepsy (LIE). All the patients underwent complex clinical examination including EEG, MRI, and PBC morphocytochemical study, which could reveal predictors for a high risk of recurrent convulsive seizure. In addition, PET was performed in 34 (72%) patients with SUGCS and 41 (82%) patients with LIE. Results and conclusion. The paper shows the possibilities of complex diagnosis using highly informative studies (PET, PBC cytomorpholog-ical examination) that allows identification of predictors of a high risk for a recurrent convulsive seizure. The findings may be useful in defining the treatment policy in patients with SUGCS and in timely using antiepileptic therapy.


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For citations:

Lipatova L.V., Vasilenko A.V., Lobzin S.V., Dyskin D.E., Stanzhevsky A.A. A single unprovoked generalized seizure: Results of examination and 5-year follow-up in 47 patients. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(2):35-38. (In Russ.)

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