Predictive capabilities of the Temperament and Character Inventory (TCI) in assessing the effectiveness of antidepressant pharmacotherapy
Abstract
Introduction. In pharmacotherapy of depressive disorders the problem of searching for the predictors of therapeutic response remains relevant. Personality predictors may be important in determining the treatment tactics.
The aim of this review is to determine the predictive capabilities of the Temperament and Character Inventory (TCI) in assessing the results of antidepressant pharmacotherapy in patients with depression (major depressive disorder).
Materials and methods. The literature search was carried out in the PubMed and GoogleScholar systems published between 1990 and november 2021. Only prospective studies were selected that examined the relationship between pre-treatment TCI scores and the effectiveness of antidepressant therapy.
Results. A total of 19 studies were found (Nsum=3559). Harm avoidance was predictor of treatment effectiveness in 11 studies (Nsum=2527), reward dependence - in 5 (Nsum=1801), and cooperativeness in 7 (Nsum=1554). In only 2 studies, personality dimensions were not associated with the effectiveness of therapy (Nsum = 234). In 11 studies (Nsum=1173) baseline values of personal characteristics were indicated, which allowed to include them into the meta-analysis.
About the Authors
A. V. Ovchinnikov
Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after V.P. Serbsky" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
T. I. Vazagaeva
Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after V.P. Serbsky" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
R. V. Akhapkin
Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after V.P. Serbsky" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
B. A. Volel
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
References
1. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006 Nov;163(11):1905-17. doi: 10.1176/ajp.2006.163.11.1905. PMID: 17074942.
2. CloningerCR. Aunifiedbiosocialtheory of personality and its role in the development of anxiety-states. PsychiatricDevelopments. 1986;4(3):167–226.
3. Cloninger, C.R., Svrakic, D.M., Przybeck, T.R., 1993. A psychobiological model of temperament and character. Arch. Gen. Psychiatry 50, 975–990.
4. Service SK et al. “A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.” Translational psychiatry vol. 2,5 e116. 15 May. 2012, doi:10.1038/tp.2012.37
5. Mulder RT: Personality pathology and treatment outcome in major depression: a review. Am J Psychiatry 2002;159:359–371
6. Olli Kampman; OutiPoutanen (2011). Can onset and recovery in depression be predicted by temperament? A systematic review and meta-analysis. , 135(1-3), 20–27. doi:10.1016/j.jad.2010.12.021
7. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009 Jul 21;339:b2700. doi: 10.1136/bmj.b2700. PMID: 19622552; PMCID: PMC2714672.
8. Study Quality Assessment Tools. U.S. Department of Health & Human Services URL:https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools (дата обращения: 20.11.2021).
9. Corruble E.; Duret C.; et al. (2002). Early and delayed personality changes associated with depression recovery? a one-year follow-up study. , 109(1), 0–25. doi:10.1016/s0165-1781(01)00366-3
10. Chien A.J; Dunner D.L (1996). The Tridimensional Personality Questionnaire in depression: State versus trait issues. , 30(1), 21–27. doi:10.1016/0022-3956(95)00041-0
11. Takahashi M, Suzuki M, Muneoka K, Tsuruoka Y, Sato K, Shirayama Y. Personality traits as predictors for the outcome of lithium augmentation in treatment-resistant depression. Psychiatry Res. 2014 Dec 30;220(3):1144-6. doi: 10.1016/j.psychres.2014.09.023. PMID: 25453642.
12. Sato T, Hirano S, Narita T, Kusunoki K, Kato J, Goto M, Sakado K, Uehara T. Temperament and character inventory dimensions as a predictor of response to antidepressant treatment in major depression. J Affect Disord. 1999 Dec;56(2-3):153-61. doi: 10.1016/s0165-0327(99)00047-6. PMID: 10701472.
13. Tomita T, Ishioka M, Kaneda A, Sugawara N, Nakagami T, Nakamura K, Yasui-Furukori N. An investigation of temperament and character inventory items for predicting the response to paroxetine treatment in patients with major depressive disorder. J Affect Disord. 2014 Aug;165:109-13. doi: 10.1016/j.jad.2014.04.076. Epub 2014 May 4. PMID: 24882186.
14. Balestri M, Porcelli S, Souery D, Kasper S, Dikeos D, et al. Temperament and character influence on depression treatment outcome. J Affect Disord. 2019 Jun 1;252:464-474. doi: 10.1016/j.jad.2019.04.031. Epub 2019 Apr 9. PMID: 31005789.
15. Hirano S.; Tetsuya S.; Tomohiro N.; et. al. (2002). Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. , 69(1-3), 31–38. doi:10.1016/s0165-0327(00)00329-3
16. Kronström K, Salminen JK, Hietala J, Kajander J, Vahlberg T, Markkula J, Rasi-Hakala H, Karlsson H. Personality traits and recovery from major depressive disorder. Nord J Psychiatry. 2011 Feb;65(1):52-7. doi: 10.3109/08039488.2010.487571. Epub 2010 May 26. PMID: 20500120.
17. Cloninger CR, Svrakic DM, Przybeck TR. Can personality assessment predict future depression? A twelve-month follow-up of 631 subjects. J Affect Disord. 2006 May;92(1):35-44. doi: 10.1016/j.jad.2005.12.034. Epub 2006 Jan 26. PMID: 16442638.
18. Farmer A, Mahmood A, Redman K, Harris T, Sadler S, McGuffin P, 2003. A sibpair study of the Temperament and Character Inventory scales in major depression. Arch. Gen. Psychiatry 60, 490–496.
19. Xia J, He Q, Li Y, et al. The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women. J AffectDisord. 2011;135(1-3):100-105. doi:10.1016/j.jad.2011.06.053
20. Гаранян, НГ. Депрессия и личность: обзор зарубежных исследований. Часть 1 / Социальная и клиническая психиатрия. – 2009. – Т. 19. – № 1. – С. 79-89.[Garanyan NG.DEPRESSION AND PERSONALITY: REVIEW OF FOREIGN INVESTIGATIONS: PART 1./ Social`naya i klinicheskaya psixiatriya.2009. – Т. 19. – № 1. (In Russ.)]
21. Calvet, B., Péricaud, M., Parneix, et al. (2016). Age and sex differences in temperament and character dimensions in a French nonclinical population. Journal of Individual Differences, 37(3), 168–180. https://doi.org/10.1027/1614-0001/a000203.
22. Quilty, Lena C.; Godfrey, Kathryn M.; Kennedy, Sidney H.; Bagby, R. Michael (2010). Harm Avoidance as a Mediator of Treatment Response to Antidepressant Treatment of Patients with Major Depression. Psychotherapyand Psychosomatics, 79(2), 116–122. doi:10.1159/000276372
23. Costa PT, McCrae RR: Revised NEO Personality Inventory (NEO-PI-R) and NEO Five Factor Inventory (NEO-FFI) Professional Manual. Odessa, Psychological Assessment Resources, 1992.
24. De Fruyt F, Van De Wiele L, Heeringen CV: Cloninger’s psychobiological model of temperament and character and the five-factor model of personality. PersIndividDif 2000; 29:441–452
25. Lena C. Quilty; Liesel-Ann C. Meusel; R. Michael Bagby (2008). Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder. , 111(1), 67–73. doi:10.1016/j.jad.2008.02.00
26. Bagby RM, Psych C, Quilty LC, Ryder AC. Personality and depression. Can J Psychiatry. 2008 Jan;53(1):14-25. doi: 10.1177/070674370805300104. PMID: 18286868.
27. Paykel ES. Partial remission, residual symptoms, and relapse in depression. Dialogues Clin Neurosci. 2008;10(4):431-437. doi:10.31887/DCNS.2008.10.4/espaykel
28. Papakostas GI, Fava M. Predictors, moderators, and mediators (correlates) of treatment outcome in major depressive disorder. Dialogues Clin Neurosci. 2008;10(4):439-451. doi:10.31887/DCNS.2008.10.4/gipapakostas
29. Perlman K, Benrimoh D, Israel S, Rollins C, Brown E, Tunteng JF, You R, You E, Tanguay-Sela M, Snook E, Miresco M, Berlim MT. A systematic meta-review of predictors of antidepressant treatment outcome in major depressive disorder. J Affect Disord. 2019 Jan 15;243:503-515. doi: 10.1016/j.jad.2018.09.067. Epub 2018 Sep 18. PMID: 30286415
30. Kraus C, Kadriu B, Lanzenberger R, Zarate CA Jr, Kasper S. Prognosis and improved outcomes in major depression: a review. Transl Psychiatry. 2019;9(1):127. Published 2019 Apr 3. doi:10.1038/s41398-019-0460-3.
31. Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoSMed. 2008;5(2):e45. doi:10.1371/journal.pmed.0050045
32. Paul R, Andlauer TFM, Czamara D, et al. Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models. Transl Psychiatry. 2019;9(1):187. Published 2019 Aug 5. doi:10.1038/s41398-019-0524-4
33. Joyce PR, Mulder RT, Cloninger CR. Temperament predicts clomipramine and desipramine response in major depression. J Affect Disord. 1994 Jan;30(1):35-46. doi: 10.1016/0165-0327(94)90149-x. PMID: 8151047.
34. Nelson E, Cloninger CR. Exploring the TPQ as a possible predictor of antidepressant response to nefazodone in a large multi-site study. J Affect Disord. 1997 Jul;44(2-3):197-200. doi: 10.1016/s0165-0327(97)00047-5. PMID: 9241580.
35. Tome MB, Cloninger CR, Watson JP, Isaac MT. Serotonergic autoreceptor blockade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol. J Affect Disord. 1997 Jul;44(2-3):101-9. doi: 10.1016/s0165-0327(97)00030-x. PMID: 9241570.
36. Newman JR, Ewing SE, McColl RD, Borus JS, Nierenberg AA, Pava J, Fava M. Tridimensional personality questionnaire and treatment response in major depressive disorder: a negative study. J Affect Disord. 2000 Jan-Mar;57(1-3):241-7. doi: 10.1016/s0165-0327(99)00046-4. PMID: 10708838.
37. Kaneda A, Yasui-Furukori N, Nakagami T, Sato Y, Kaneko S. The influence of personality factors on paroxetine response time in patients with major depression. J Affect Disord. 2011 Dec;135(1-3):321-5. doi: 10.1016/j.jad.2011.06.050. Epub 2011 Jul 23. PMID: 21784533.
38. Gurpegui D, Ortuño F, Gurpegui M. Temperament traits and remission of depression: A naturalistic six-month longitudinal study. J Affect Disord. 2019 Jan 15;243:494-502. doi: 10.1016/j.jad.2018.09.041. Epub 2018 Sep 17. PMID: 30286414.
39. Marijnissen G, Tuinier S, Sijben AE, Verhoeven WM. The temperament and character inventory in major depression. J AffectDisord. 2002 Jul;70(2):219-23. doi: 10.1016/s0165-0327(01)00364-0. PMID: 12117635.
40. Abrams KY, Yune SK, Kim SJ, Jeon HJ, Han SJ, Hwang J, Sung YH, Lee KJ, Lyoo IK. Trait and state aspects of harm avoidance and its implication for treatment in major depressive disorder, dysthymic disorder, and depressive personality disorder. PsychiatryClinNeurosci. 2004 Jun;58(3):240-8. doi: 10.1111/j.1440-1819.2004.01226.x. PMID: 15149288.
41. Köhler-Forsberg O, Keers R, Uher R, et al. Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram. Psychol Med. 2021 Nov 12:1-9. doi: 10.1017/S003329172100444X. Epub ahead of print. PMID: 34763734.
42. Joffe RT, Bagby RM, Levitt AJ, Regan JJ, Parker JD: The Tridimensional Personality Questionnaire in major depression. Am J Psychiatry 1993; 150:959–960. doi: 10.1176/ajp.150.6.959. PMID: 8494077.
43. Kampman O, Poutanen O, Illi A, Setälä-Soikkeli E, Viikki M, Nuolivirta T, Leinonen E. Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients. Eur Psychiatry. 2012 May;27(4):245-9. doi: 10.1016/j.eurpsy.2010.07.006. Epub 2010 Oct 8. PMID: 20933372.
44. Mulder RT, Joyce PR, Frampton CM, Luty SE, Sullivan PF. Six months of treatment for depression: outcome and predictors of the course of illness. Am J Psychiatry. 2006 Jan;163(1):95-100. doi: 10.1176/appi.ajp.163.1.95. PMID: 16390895.
45. Nishioka G., Yashima H.; Kiuchi Y., et al. (2013). Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder. Human Psychopharmacology: Clinical and Experimental, 28(6), 576–585. doi:10.1002/hup.2347
Review
For citations:
Ovchinnikov A.V., Vazagaeva T.I., Akhapkin R.V., Volel B.A. Predictive capabilities of the Temperament and Character Inventory (TCI) in assessing the effectiveness of antidepressant pharmacotherapy. Neurology, Neuropsychiatry, Psychosomatics. (In Russ.)
Views: 104
Email this article 