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Cognitive impairment in patients with coronavirus infection

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The pathogenesis of the development of cognitive impairment (CI) associated with the SARS-CoV-2 virus is complex and includes the direct neurotoxic effect of the virus, vascular, disimmune factors, artificial lung ventilation, and adverse psychological consequences of social isolation. The relationship between CI and SARS-CoV-2 infection appears to be two-way: patients with premorbid CI have a higher risk of infection, severe illness, and death; on the other hand, past infection with SARS-CoV-2 may stimulate the clinical onset and progression of CI, including Alzheimer's disease. For the treatment of severe CI after COVID-19, memantine (akatinol memantine) is recommended.

About the Authors

Y. A. Starchina
Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Yulia Aleksandrovna Starchina
119021, Moscow, Rossolimo St., 11, Build. 1

Competing Interests:

The conflict of interest has not affected the results of the investigation.

O. V. Kosivtsova
Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

119021, Moscow, Rossolimo St., 11, Build. 1

Competing Interests:

The conflict of interest has not affected the results of the investigation.


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Starchina Y.A., Kosivtsova O.V. Cognitive impairment in patients with coronavirus infection. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(4):96-102. (In Russ.)

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