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Cognitive and emotional disorders in patients with chronic heart failure: prospects for detection and correction

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The article presents current data on the prevalence of anxiety, depressive disorders and cognitive impairment in patients with chronic heart failure (CHF). Data on the main pathogenetic mechanisms of the relationship in the development of emotional and cognitive impairments in patients with CHF are summarized. Recommendations for screening for cognitive and emotional disorders in this patient are given. The prospects for the correction of these disorders in patients with CHF are discussed, including within the framework of interdisciplinary cooperation.

About the Author

V. N. Shishkova
National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of Russia; A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation

10, Petroverigsky Lane, Build. 3, Moscow 101990;

20, Delegatskaya Str., Build. 1, Moscow 127473


1. Tereshchenko SN, Galyavich AS, Uskach TM, et al. 2020 Clinical practice guidelines for chronic heart failure. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2020;25(11):311-74. doi:10.15829/1560-4071-2020-4083 (In Russ.).

2. Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-337. doi: 10.1093/eurheartj/ehab484

3. Ageev FT, Belenkov YuN, Fomin IV, et al. Prevalence of chronic heart failure in European area of Russian Federation – data from EPOCH-HF. Serdechnaya nedostatochnost. 2006;7(1):112-5 (In Russ.).

4. Celano CM, Villegas AC, Albanese AM, et al. Depression and anxiety in heart failure: a review. Harv Rev Psychiatry. Jul/Aug 2018;26(4):175-84. doi: 10.1097/HRP.0000000000000162

5. Jha MK, Qamar A, Vaduganathan M, et al. Screening and Management of Depression in Patients with cardiovascular disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;73(14):1827-45. doi: 10.1016/j.jacc.2019.01.041

6. Shishkova VN, Kotova MB, Kapustina LA, Imamgayazova KE. Issues of pathogenesis of cognitive and psychoemotional disorders in patients with cardiovascular and metabolic diseases. Terapiya. 2021;50(8):158-63. doi: 10.18565/therapy.2021.8.158-163 (In Russ.).

7. Shishkova VN, Ustarbekova DB, Shishkov VA, et al. Psycho-emotional disorders in chronic heart failure patients. Terapiya. 2022;8(1):44-9. doi: 10.18565/therapy.2022.1.44-49 (In Russ.).

8. Rutledge T, Reis VA, Linke SE, et al. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37. doi: 10.1016/j.jacc.2006.06.055. Epub 2006 Sep 26.

9. Daskalopoulou M, George J, Walters K, et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1. 9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016.

10. Frasure-Smith N, Lesperance F, Habra M, et al. Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation. 2009 Jul 14;120(2):134-40, 3p following 140. doi: 10.1161/CIRCULATIONAHA.109.851675. Epub 2009 Jun 29.

11. Easton K, Coventry P, Lovell K, et al. Prevalence and measurement of anxiety in samples of patients with heart failure: meta-analysis. J Cardiovasc Nurs. Jul-Aug 2016;31(4):367-79. doi: 10.1097/JCN.0000000000000265

12. Roy SS, Foraker RE, Girton RA, et al. Posttraumatic stress disorder and incident heart failure among a community-based sample of US veterans. Am J Public Health. 2015 Apr;105(4):757-63. doi: 10.2105/AJPH.2014.302342. Epub 2015 Feb 25.

13. Celano CM, Millstein RA, Bedoya CA, et al. Association between anxiety and mortality in patients with coronary artery disease: a meta-analysis. Am Heart J. 2015 Dec;170(6):1105-15. doi: 10.1016/j.ahj.2015.09.013. Epub 2015 Sep 21.

14. Alhurani AS, Dekker RL, Abed MA, et al. The association of co-morbid symptoms of depression and anxiety with all-cause mortality and cardiac rehospitalization in patients with heart failure. Psychosomatics. Jul-Aug 2015;56(4):371-80. doi: 10.1016/j.psym.2014.05.022. Epub 2014 Jun 2.

15. Vaccarino V, Badimon L, Bremner JD, et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J. 2020 May 1;41(17):1696. doi: 10.1093/eurheartj/ehz811

16. Mene-Afejuku TO, Pernia M, Ibebuogu UN, et al. Heart failure and cognitive impairment: clinical relevance and therapeutic considerations. Curr Cardiol Rev. 2019;15(4):291-303. doi: 10.2174/1573403X15666190313112841

17. Ovsenik A, Podbregar M, Fabjan A. Cerebral blood flow impairment and cognitive decline in heart failure. Brain Behav. 2021 Jun;11(6):e02176. doi: 10.1002/brb3.2176. Epub 2021 May 14.

18. Gruhn N, Larsen F, Boesgaard S, et al. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke. 2001 Nov;32(11):2530-3. doi: 10.1161/hs1101.098360

19. Cannon JA, Moffitt P, Perez-Moreno AC, et al. Cognitive impairment and heart failure: Systematic review and meta-analysis. J Card Fail. 2017 Jun;23(6):464-75. doi: 10.1016/j.cardfail.2017.04.007. Epub 2017 Apr 19.

20. Cameron J, Worrall-Carter L, Page K, et al. Screening for mild cognitive impairment in patients with heart failure: Montreal Cognitive Assessment versus Mini Mental State Exam. Eur J Cardiovasc Nurs. 2013 Jun;12(3):252-60. doi: 10.1177/1474515111435606. Epub 2012 Apr 18.

21. Albus C, Waller C, Fritzsche K, et al. Significance of psychosocial factors in cardiology: update 2018: Position paper of the German Cardiac Society. Clin Res Cardiol. 2019 Nov;108(11):1175-96. doi: 10.1007/s00392-019-01488-w. Epub 2019 May 10.

22. Riedl D, Schüssler G. The Infuence of doctor-patient communication on health outcomes: a systematic review. Z Psychosom Med Psychother. 2017 Jun;63(2):131-50. doi: 10.13109/zptm.2017.63.2.131

23. Kim JM, Stewart R, Kang HJ, et al. Long-term cardiac outcomes of depression screening, diagnosis and treatment in patients with acute coronary syndrome: the DEPACS study. Psychol Med. 2021 Apr;51(6):964-74. doi: 10.1017/S003329171900388X. Epub 2020 Jan 7.

24. He W, Zhou Y, Ma J, et al. Effect of antidepressants on death in patients with heart failure: a systematic review and metaanalysis. Heart Fail Rev. 2020 Nov;25(6):919-6. doi: 10.1007/s10741-019-09850-w

25. Evans MA, Golomb BA. Statin-associated adverse cognitive effects: Survey results from 171 patients. Pharmacotherapy. 2009 Jul;29(7):800-11. doi: 10.1592/phco.29.7.800

26. Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM. Statin-Associated Memory Loss: Analysis of 60 Case Reports and Review of the Literature. Pharmacotherapy. 2003 Jul;23(7):871-80. doi: 10.1592/phco.23.7.871.32720

27. He Q, Li Q, Zhao J, et al. Relationship between plasma lipids and mild cognitive impairment in the elderly Chinese: A case-control study. Lipids Health Dis. 2016 Sep 5;15(1):146. doi: 10.1186/s12944-016-0320-6

28. Liao JN, Chao TF, Liu CJ, et al. Risk and prediction of dementia in patients with atrial fibrillationea nationwide populationbased cohort study. Int J Cardiol. 2015 Nov 15;199:25-30. doi: 10.1016/j.ijcard.2015.06.170. Epub 2015 Jul 6.

29. Rojas-Fernandez CH, Goldstein LB, Levey AI, et al. An assessment by the Statin Cognitive Safety Task Force: 2014 update. J Clin Lipidol. May-Jun 2014;8(3 Suppl):S5-16. doi: 10.1016/j.jacl.2014.02.013

30. Parfenov VA. Distsirkulyatornaya entsefalopatiya i sosudistyye kognitivnyye rasstroystva [Dyscirculatory encephalopathy and vascular cognitive disorders]. Moscow: IMA-PRESS; 2017. 128 p. (In Russ.).

31. Shishkova VN, Malyukova NG, Tokareva RB. The study of cereton efficacy in complex neurorehabilitation therapy. Lechebnoye delo. 2020;(1):55-62 (In Russ.).

32. Kamchatnov PR, Abusueva BA, Evzel'man MA, et al. Efficacy of cereton in acute ischemic stroke: results of the trial SOLNTSE. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2012;112(3-2):10-4 (In Russ.).

33. Buyvolova TV, Glotova ME, Khalak ME, et al. The use of cereton in the rehabilitation of patients with hemorrhagic stroke. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2009;109(5 Suppl 2):57-61 (In Russ.).

34. Shakhparova NV, Kadykov AS. The use of choline alfoscerate in patients with poststroke cognitive impairment. Trudnyy patsiyent. 2011;9(1):27-30 (In Russ.).

35. Singh M, Khan MI, Giri R, Kumar L. Rol of citicoline in improvement of cognition, memory and post stroke disability in stroke patients. Int J Advances Med. 2019;6(2):429. doi: 10.18203/2349-3933.ijam20191154

36. Bogolepova AN. The role of oxidative stress in the development of vascular cognitive disorders. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(8):133-9 (In Russ.).

37. Shishkova VN, Adasheva TV. Current perspectives in the mechanisms of development of cognitive impairment in patients with cardiovascular diseases and opportunities for their improvement. Nervnyye bolezni. 2021;(2):41-6. doi: 10.24412/2226-0757-2021-12317 (In Russ.).

38. Solov'eva EYu, Karneev AN, Chekanov AV, et al. The study of the membrane-protective potential of the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018;118(1):18-22. doi: 10.17116/jnevro20181181118-22 (In Russ.).

39. Solovyeva EYu, Karneev AN, Chekanov AV, et al. The study of membrane-protectiveand and antioxidant potentials of citicoline and ethylmethylhydroxypyridine with combined usage. Tikhookeanskiy meditsinskiy zhurnal = Pacific Medical Journal. 2019;(1):74-80. doi: 10.17238/PmJ1609-1175.2019.1.74-80 (In Russ.).

40. Soloveva EYu, Amelina IP. Cerebral small vessel disease's impact on the development of chronic cerebral ischemia: paradigms of treatment. Meditsinskiy sovet = Medical Council. 2020;(2):16-24. doi: 10.21518/2079-701X-2020-2-16-24 (In Russ.).


For citations:

Shishkova V.N. Cognitive and emotional disorders in patients with chronic heart failure: prospects for detection and correction. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(3):87-93. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)