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Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients

https://doi.org/10.14412/2074-2711-2022-3-12-18

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Abstract

Objective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients.

Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G.

Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients.

Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms.

About the Authors

V. V. Gusev
Ural State Medical University, Ministry of Health of Russia; Ural Federal University named after the first President of Russia B. N.Yeltsin, Yekaterinburg; Central City Clinical Hospital № 23
Russian Federation

13, Repina St., Yekaterinburg 620028;

19, Mira St., Yekaterinburg 620002;

39, Starikh Bolshevikov St., Yekaterinburg 620017



O. P. Kovtun
Ural State Medical University, Ministry of Health of Russia
Russian Federation

3, Repina St., Yekaterinburg 620028



O. A. Lvova
Ural State Medical University, Ministry of Health of Russia; Ural Federal University named after the first President of Russia B. N.Yeltsin
Russian Federation

3, Repina St., Yekaterinburg 620028;

19, Mira St., Yekaterinburg 620002



E. A. Partylova
Sverdlovskaya Regional Clinical Hospital № 1
Russian Federation

185, Volgogradskaya St., Yekaterinburg 620102



A. P. Sergeev
Ural Federal University named after the first President of Russia B. N.Yeltsin; Institute of Industrial Ecology, Ural Branch of Russian Academy of Science
Russian Federation

19, Mira St., Yekaterinburg 620002;

20, S. Kovalevskoy St., Yekaterinburg 620990



M. V. Sergeeva
Institute of Industrial Ecology, Ural Branch of Russian Academy of Science
Russian Federation

20, S. Kovalevskoy St., Yekaterinburg 620990



I. T. Yanchuk
Ural State Medical University, Ministry of Health of Russia
Russian Federation

3, Repina St., Yekaterinburg 620028



D. A. Dobrazova
Ural State Medical University, Ministry of Health of Russia
Russian Federation

3, Repina St., Yekaterinburg 620028



P. A. Suvorkov
Ural State Medical University, Ministry of Health of Russia
Russian Federation

3, Repina St., Yekaterinburg 620028



N. A. Shamalov
Research Institute of Cerebrovascular Pathology and Stroke, Federal Center for Brain and Neurotechnologies of Federal Medical and Biological Agency
Russian Federation

1, Ostrovityanova St., Build. 1, Moscow 117513



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For citations:


Gusev V.V., Kovtun O.P., Lvova O.A., Partylova E.A., Sergeev A.P., Sergeeva M.V., Yanchuk I.T., Dobrazova D.A., Suvorkov P.A., Shamalov N.A. Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(3):12-18. https://doi.org/10.14412/2074-2711-2022-3-12-18

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)