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Early-onset Alzheimer's disease

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Alzheimer's disease (AD) is the most common cause of cognitive impairment in adults. There are two main forms of AD: early-onset (onset before 65 years) and late-onset (onset after 65 years). Early-onset AD accounts for at least 5% of all disease cases. The risk of early-onset AD increases in the presence of a family burden and a history of traumatic brain injury. However, it is less associated with cerebrovascular disease, diabetes mellitus, and obesity compared to late-onset AD. The article provides a review of current publications on the diagnostic and treatment problems in early forms of AD. Clinical, neuropsychological and neuroimaging differences between AD with early and late onset are presented.

On the example of a clinical observation of a patient with AD with an onset at the age of 38 years, stabilization of the cognitive defect for 6 months and a decrease in the severity of emotional and behavioral disorders after Akatinol Memantine administration are shown. The main problems of management of young patients with AD are considered.

About the Authors

A. B. Lokshina
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Anastasia Borisovna Lokshina

11, Rossolimo St., Build. 1, Moscow 119021, Russia

D. A. Grishina
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

11, Rossolimo St., Build. 1, Moscow 119021, Russia 

A. V. Obukhova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

11, Rossolimo St., Build. 1, Moscow 119021, Russia 


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For citations:

Lokshina A.B., Grishina D.A., Obukhova A.V. Early-onset Alzheimer's disease. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(2):110-116. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)