Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

COVID-19 associated multiple cranial neuropathies

https://doi.org/10.14412/2074-2711-2022-1-99-103

Full Text:

Abstract

The polymorphism of the clinical manifestations of coronavirus infection often creates great diagnostic difficulties for the practitioners, especially in patients with a predominance of neurological symptoms. Of the latter, cranial neuropathies take a particular place, as they may be either one of the first symptoms or appear during the disease progression. Impairment of smell and taste is considered an early manifestation of SARS-CoV2 infection. Similar to the involvement of the olfactory bulb, multiple cranial nerves involvement (for example, VII, VI, and III) has been described. Patients with COVID-19 associated multiple cranial neuropathies are more likely to experience partial recovery of impaired function. We present and discuss a rare case of COVID-19 associated multiple cranial neuropathies with a sequential involvement of the olfactory (I), right visual (II), frontal branch of the trigeminal (V), facial (VII), and hypoglossal (XII) nerves. Data on clinical manifestations and diagnostic criteria for this form of pathology are presented. 

About the Authors

M. Yu. Maksimova
Research Center of Neurology
Russian Federation

80, Volokolamskoe Shosse, Moscow 125367



Ya. O. Grusha
Research Institute of Eye Diseases; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

11A,B, Rossolimo St., Build. 1, Moscow 119021;

Department of Eye Diseases, 8, Trubetskaya St., Build. 2, Moscow 119991



E. I. Fettser
Research Institute of Eye Diseases; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

11A,B, Rossolimo St., Build. 1, Moscow 119021;

Department of Eye Diseases, 8, Trubetskaya St., Build. 2, Moscow 119991



References

1. Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64. doi: 10.1128/MMBR.69.4.635-664.2005

2. Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res. 2013 Oct;100(1):286-95. doi: 10.1016/j.antiviral.2013.08.015. Epub 2013 Sep 6.

3. Alshukairi AN, Zheng J, Zhao J, et al. High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia. mBio. 2018 Oct 30;9(5):e01985-18. doi: 10.1128/mBio.01985-18

4. World Health Organization. II march 2020. Available from: httph:/www.int/ru/dg/speeches/detail/who-director-general-s-openingremarks-at-the-media-briefing-on-covid-19 5. He F, Deng Y, Li W. Coronavirus disease 2019: What we know? J Med Virol. 2020 Jul;92(7):719-25. doi: 10.1002/jmv.25766. Epub 2020 Mar 28.

5. Natoli S, Oliveira V, Calabresi P, et al. Does SARS-Cov-2 invade the brain? Translational lessons from animal models. Eur J Neurol. 2020 Sep;27(9):1764-73. doi: 10.1111/ene.14277. Epub 2020 May 22.

6. Guan WJ, Ni ZY, Hu Y, et al; China Medical Treatment Expert Group for Covid-19 ClinicalCharacteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-20. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

7. Paterson RW, Brown RL, Benjamin L, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020 Oct 1;143(10):3104-20. doi: 10.1093/brain/awaa240

8. Andalib S, Biller J, Di Napoli M, et al. Peripheral Nervous System Manifestations Associated with COVID-19. Curr Neurol Neurosci Rep. 2021 Feb 14;21(3):9. doi: 10.1007/s11910-021-01102-5

9. Hui KPY, Cheung MC, Perera RAPM, et al. Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures. Lancet Respir Med. 2020 Jul;8(7):687-95. doi: 10.1016/S2213-2600(20)30193-4. Epub 2020 May 7.

10. World Health Organization. Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance, 2 March 2020. World Health Organization. Available from: https://apps.who.int/iris/handle/10665/331329

11. Serrano GE, Walker JE, Arce R, et al. Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease. medRxiv. 2021 Feb 18:2021.02.15.21251511. doi: 10.1101/2021.02.15.21251511

12. Yachou Y, El Idrissi A, Belapasov V, Ait Benali S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. 2020 Oct;41(10):2657-69. doi: 10.1007/s10072-020-04575-3. Epub 2020 Jul 28.

13. Gholami M, Safari S, Ulloa L, Motaghinejad M. Neuropathies and neurological dysfunction induced by coronaviruses. J Neurovirol. 2021 Jun;27(3):380-96. doi: 10.1007/s13365-021-00977-x. Epub 2021 May 13.

14. Finsterer J, Scorza FA, Scorza C, Fiorini A. COVID-19 associated cranial nerve neuropathy: A systematic review. Bosn J Basic Med Sci. 2021 Aug 11. doi: 10.17305/bjbms.2021.6341. Online ahead of print.

15. Lüers JC, Klussmann JP, Guntinas-Lichius O. The COVID-19pandemic and otolaryngology: What it comes down to? Laryngorhinootologie. 2020 May;99(5):287-91. doi: 10.1055/a-1095-2344. Epub 2020 Mar 26.

16. Sharifian-Dorche M, Huot P, Osherov M, et al. Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. J Neurol Sci. 2020 Oct 15;417:117085. doi: 10.1016/j.jns.2020.117085. Epub 2020 Aug 7.

17. Kandemirli SG, Altundag A, Yildirim D, et al. Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia. Acad Radiol. 2021 Jan;28(1):28-35. doi: 10.1016/j.acra.2020.10.006. Epub 2020 Oct 19.

18. Bilinska K, von Bartheld CS, Butowt R. Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19. Front Cell Neurosci. 2021 Jul 5;15:674123. doi: 10.3389/fncel.2021.674123. eCollection 2021.

19. Lima MA, Silva MTT, Soares CN, et al. Peripheral facialnerve palsy associated with COVID-19. J Neurovirol. 2020 Dec;26(6):941-4. doi: 10.1007/s13365-020-00912-6. Epub 2020 Oct 2.


Review

For citations:


Maksimova M.Yu., Grusha Y.O., Fettser E.I. COVID-19 associated multiple cranial neuropathies. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(1):99-103. (In Russ.) https://doi.org/10.14412/2074-2711-2022-1-99-103

Views: 474


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)