Skeletal muscle involvement in patients with chronic alcoholic intoxication
https://doi.org/10.14412/2074-2711-2013-2396
Abstract
Chronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, biochemical, electromyographic, and morphological examination was made in 51 patients with chronic alcoholic intoxication. Morphological and morphometric studies were shown to play a determining role in the diagnosis of CAM. The clinical manifestations of skeletal muscle involvement corresponded to the magnitude of the atrophic process. Abnormalities were found in the basic components of protein synthesis at both the intracellular and systemic levels of regulation.
About the Authors
Olga Evgenyevna ZinovyevaDepartment of Nervous System Diseases
N S Shcheglova
Department of Nervous System Diseases
Y V Kazantseva
Department of Nervous System Diseases
B S Shenkman
E G Altayeva
References
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Review
For citations:
Zinovyeva O.E., Shcheglova N.S., Kazantseva Y.V., Shenkman B.S., Altayeva E.G. Skeletal muscle involvement in patients with chronic alcoholic intoxication. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(1):39-42. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2396
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