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Treatment of noncognitive neuropsychiatric disorders in Alzheimer's disease

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Alzheimer's disease (AD) is the most common neurodegenerative disease, which is caused by cerebral amyloidosis. Noncognitive neuropsychiatric disorders (NСNPDs) include emotional, behavioral disorders, as well as psychotic symptoms. NСNPDs are almost an obligatory manifestation of this disease, accompany cognitive impairment and are detected at all stages of the disease – from preclinical to the severe dementia stage. As an example, we present a case report of a female patient with mild dementia in AD in whom Akatinol memantine administration resulted in the stabilization of a cognitive defect within one year and a decrease in the severity of emotional and behavioral disorders. The article discusses the indications and contraindications for antipsychotic administration in this disease, NСNPDs treatment in AD, which includes nonpharmacological and pharmacological methods. Accurate analysis of NСNPDs allows to predict the disease course, optimize the treatment, and thereby improve the quality of life of the patient and his relatives and caregivers.

About the Authors

A. B. Lokshina
N.V. Sklifosovsky Institut of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Build. 1, Moscow 119021, Russia 

D. A. Grishina
N.V. Sklifosovsky Institut of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Build. 1, Moscow 119021, Russia 


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For citation:

Lokshina A.B., Grishina D.A. Treatment of noncognitive neuropsychiatric disorders in Alzheimer's disease. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(6):132-138. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)