Biological basis of aggressive behavior
https://doi.org/10.14412/2074-2711-2021-5-76-82
Abstract
The review analyzes the role of serotonergic, dopaminergic, noradrenergic, and glutamatergic systems and neuroendocrine mechanisms, neuropeptides, and inflammatory mediators in aggression manifestation. We discuss the inconsistency of modern concepts about the neurochemical nature of aggressive behavior and the urgency of determining biological markers of social danger. Finally, questions of psychopharmacotherapy of aggressive behavior are reviewed.
About the Authors
O. A. Makushkina
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation
Russian Federation
Oksana Anatolevna Makushkina
23, Kropotkinskiy per., Moscow 119034
O. I. Gurina
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation
Russian Federation
23, Kropotkinskiy per., Moscow 119034
V. A. Golenkova
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation
Russian Federation
23, Kropotkinskiy per., Moscow 119034
References
1. Brown GL, Goodwin FK, Ballenger JC, et al. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979 Oct;1(2):131-9. doi: 10.1016/0165-1781(79)90053-2
2. Duke AA, Begue L, Bell R, Eisenlohr-Moul T. Revisiting the serotonin-aggression relation in humans: a meta-analysis. Psychol Bull. 2013 Sep;139(5):1148-72. doi: 10.1037/a0031544
3. Moller SE, Mortensen EL, Breum L, et al. Aggression and personality: association with amino acids and monoamine metabolites. Psychol Med. 1996 Mar;26(2):323-31. doi: 10.1017/s0033291700034711
4. Prochazka H, Agren H. Self-rated aggression and cerebral monoaminergic turnover. Sex differences in patients with persistent depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2003 Aug;253(4):185-92. doi: 10.1007/s00406-003-0423-8
5. Kogan BM, Drozdov AZ. Pathogenetic mechanisms in the development of depressive disorders. Sistemnaya psikhologiya i sotsiologiya. 2013;(7):46-50 (In Russ.).
6. Coccaro EF, Lee R. Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects. J Neural Transm (Vienna). 2010 Feb;117(2):241-8. doi: 10.1007/s00702-009-0359-x
7. Soderstrom H, Blennow K, Manhem A, Forsman A. CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy. J Neural Transm (Vienna). 2001;108(7):869-78. doi: 10.1007/s007020170036
8. Coccaro EF, Fanning JR, Phan KL, et al. Serotonin and impulsive aggression. CNS Spectr. 2015 Jun;20(3):295-302. doi: 10.1017/S1092852915000310
9. Hagenbeek FA, Kluft C, Hankemeier T, et al. Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):719-32. doi: 10.1002/ajmg.b.32435
10. Comai S, Bertazzo A, Vachon J, et al. Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Oct 3;70:8-16. doi: 10.1016/j.pnpbp.2016.04.012
11. Tiihonen J, Virkkunen M, Rasanen P, et al. Free L-tryptophan plasma levels in antisocial violent offenders. Psychopharmacology (Berl). 2001 Oct;157(4):395-400. doi: 10.1007/s002130100842
12. Soderstrom H, Blennow K, Forsman A, et al. A controlled study of tryptophan and cortisol in violent offenders. J Neural Transm (Vienna). 2004 Dec;111(12):1605-10. doi: 10.1007/s00702-004-0219-7
13. Manchia M, Comai S, Pinna M, et al. Biomarkers in aggression. Adv Clin Chem. 2019;93:169-237. doi: 10.1016/bs.acc.2019.07.004
14. Narvaes R, Martins de Almeida RM. Aggressive behavior and three neurotransmitters: dopamine, GABA, and serotonin A review of the last 10 years. Psychol Neurosci. 2014 Jun;7(4):601-7. doi: 10.3922/j.psns.2014.4.20
15. Rosell DR, Siever LJ. The neurobiology of aggression and violence. CNS Spectr. 2015 Jun;20(3):254-79. doi: 10.1017/S109285291500019X
16. Giotakos O, Markianos M, Vaidakis N, et al. Aggression, impulsivity, plasma sex hormones, and biogenic amine turnover in a forensic population of rapists. J Sex Marital Ther. 2003 May-Jun;29(3):215-25. doi: 10.1080/00926230390155113
17. Daderman AM, Lidberg L. Relapse in violent crime in relation to cerebrospinal fluid monoamine metabolites (5-HIAA, HVA and HMPG) in male forensic psychiatric patients convicted of murder: a 16-year follow-up. Acta Psychiatr Scand. 2002 Jun;106(s412):71-4. doi: 10.1034/j.16000447.106.s412.16.x
18. Ramirez-Bermudez J, Perez-Neri I, Montes S, et al. Imbalance between nitric oxide and dopamine may underly aggression in acute neurological patients. Neurochem Res. 2010 Oct;35(10):1659-65. doi: 10.1007/s11064-010-0227-y
19. Terbeck S, Savulescu J, Chesterman LP, Cowen PJ. Noradrenaline effects on social behavior, intergroup relations, and moral decisions. Neurosci Biobehav Rev. 2016 Jul;66:54-60. doi: 10.1016/j.neubiorev.2016.03.031
20. Comai S, Tau M, Gobbi G. The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology. J Clin Psychopharmacol. 2012 Feb;32(1):83-94. doi: 10.1097/JCP.0b013e31823f8770
21. Cheng J, Xiong Z, Duffney LJ, et al. Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors. Biol Psychiatry. 2014 Dec 15;76(12):953-62. doi: 10.1016/j.biopsych.2014.04.003
22. Coccaro EF, Lee R, McCloskey M. Norepinephrine Function in Personality Disorder: Plasma Free MHPG Correlates Inversely with Life History of Aggression. CNS Spectrums. 2003 Oct;8(10):731-6. doi: 10.1017/s1092852900019106
23. Chichinadze KN, Domianidze TR, Matitaishvili TTs, et al. Possible relation of plasma testosterone level to aggressive behavior of male prisoners. Bull Exp Biol Med. 2010 Jul;149(1):7-9. doi: 10.1007/s10517-010-0861-z
24. Miczek KA, DeBold JF, Gobrogge K, et al. The Role of Neurotransmitters in Violence and Aggression. In: Sturmey P, editor. The Wiley Handbook of Violence and Aggression. New York; 2017. P. 1-13. doi: 10.1002/9781119057574.whbva019
25. Gulsun M, Oznur T, Aydemir E, et al. Possible relationship between amino acids, aggression and psychopathy. Int J Psychiatry Clin Pract. 2016;20(2):91-100. doi: 10.3109/13651501.2016.1144771
26. Kibitov AO, Kuznetsova MN. Molecular mechanism of alcohol addiction: the role of glutamate receptors of the brain. Voprosy narkologii. 2019;5(176):58-98. doi: 10.47877/0234-0623_2019_5_58 (In Russ.).
27. Coccaro EF, Lee R, Vezina P. Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects. J Psychiatr Res. 2013 Sep;47(9):1247-53. doi: 10.1016/j.jpsychires.2013.05.001
28. Bjork JM, Moeller FG, Kramer GL, et al. GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Res. 2001 Mar 25;101(2):131-6. doi: 10.1016/s0165-1781(01)00220-7
29. Lee R, Petty F, Coccaro EF. Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects. J Psychiatr Res. 2009 Jan;43(4):353-9. doi: 10.1016/j.jpsychires.2008.04.004
30. Miczek KA, Fish EW, De Bold JF. Neurosteroids, GABAA receptors, and escalated aggressive behavior. Horm Behav. 2003 Sep;44(3):242-57. doi: 10.1016/j.yhbeh.2003.04.002
31. Yu YZ, Shi JX. Relationship between levels of testosterone and cortisol in saliva and aggressive behaviors of adolescents. Biomed Environ Sci. 2009 Feb;22(1):44-9. doi: 10.1016/S0895-3988(09)60021-0
32. Horn M, Potvin S, Allaire JF, et al. Male inmate profiles and their biological correlates. Can J Psychiatry. 2014 Aug;59(8):441-9. doi: 10.1177/070674371405900807
33. Pajer K, Tabbah R, Gardner W, et al. Adrenal androgen and gonadal hormone levels in adolescent girls with conduct disorder. Psychoneuroendocrinology. 2006 Nov;31(10):1245-56. doi: 10.1016/j.psyneuen.2006.09.005
34. Maras A, Laucht M, Gerdes D, et al. Association of testosterone and dihydrotestosterone with externalizing behavior in adolescent boys and girls. Psychoneuroendocrinology. 2003 Oct;28(7):932-40. doi: 10.1016/s0306-4530(02)00119-1
35. Dmitrieva TN, Oades RD, Hauffa BP, Eggers C. Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons for growth factors, thyroid and gonadal hormones. Neuropsychobiology. 2001;43(3):134-40. doi: 10.1159/000054881
36. Archer J, Graham-Kevan N, Davies M. Testosterone and aggression: A reanalysis of Book, Starzyk, and Quinsey's (2001) study. Aggres Violent Behav. 2005 Feb;10(2):241-61. doi: 10.1016/j.avb.2004.01.001
37. Uzbekov MG, Maksimova NM, Brilliantova VV, et al. On the issue of biological markers of efficiency of therapy of mental and neurological diseases. Sibirskiy vestnik psikhiatrii i narkologii. 2018;2(99):5-14. doi: 10.26617/1810-3111-2018-2(99)-5-14 (In Russ.).
38. Terburg D, Morgan B, van Honk J. The testosterone-cortisol ratio: A hormonal marker for proneness to social aggression. Int J Law Psychiatry. 2009 Jul-Aug;32(4):216-23. doi: 10.1016/j.ijlp.2009.04.008
39. Montoya ER, Terburg D, Bos PA, van Honk J. Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective. Motiv Emot. 2012 Mar;36(1):65-73. doi: 10.1007/s11031-011-9264-3
40. De Jong TR, Neumann ID. Oxytocin and Aggression. Curr Top Behav Neurosci. 2018;35:175-92. doi: 10.1007/7854_2017_13
41. Caldwell HK, Lee HJ, Macbeth AH, Young WS 3rd. Vasopressin: behavioral roles of an «original» neuropeptide. Prog Neurobiol. 2008 Jan;84(1):1-24. doi: 10.1016/j.pneurobio.2007.10.007
42. Dadds MR, Moul C, Cauchi A, et al. Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy. Dev Psychopathol. 2014 Feb;26(1):33-40. doi:10.1017/S0954579413000497
43. Ivanova GP, Gorobets LN. Modern views on clinical psychopathological and immunoendocrine interactions in autoimmune thyroiditis. Part II. Sotsial'naya i klinicheskaya psikhiatriya. 2011;21(1):68-75 (In Russ.).
44. Miller AH, Haroon E, Raison CL, Felger JC. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety. 2013 Apr;30(4):297-306. doi: 10.1002/da.22084
45. Shilov YuE. Novye metody opredeleniya metabolitov triptofana v trombotsitakh I plazme krovi cheloveka dlya laboratornoi diagnostiki depressivnykh rasstroistv: Avtoref. dis. .... kand. biol. nauk [New methods for the determination of tryptophan metabolites in human platelets and blood plasma for laboratory diagnostics of depressive disorders: Abstract. dis. ... cand. biol. nauk]. Moscow; 2014. 26 p. (In Russ.).
46. Coccaro EF. Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study. J Psychiatr Res. 2006 Aug;40(5):460-5. doi: 10.1016/j.jpsychires.2005.04.005
47. Holtmann M, Poustka L, Zepf FD, et al. Severe affective and behavioral dysregulation in youths is associated with a proinflammatory state. Z Kinder Jugendpsychiatr Psychother. 2013 Nov;41(6):393-9. doi: 10.1024/1422-4917/a000255
48. Marsland AL, Prather AA, Petersen KL, et al. Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality. Brain Behav Immun. 2008 Jul;22(5):753-61. doi: 10.1016/j.bbi.2007.11.008
49. Siegel A, Bhatt S, Bhatt R, Zalcman SS. The neurobiological bases for development of pharmacological treatments of aggressive disorders. Curr Neuropharmacol. 2007;5(2):135-47. doi: 10.2174/157015907780866929
50. Lane SD, Kjome KL, Moeller FG. Neuropsychiatry of aggression. Neurol Clin. 2011 Feb;29(1):49-64. doi: 10.1016/j.ncl.2010.10.006
51. Frogley C, Taylor D, Dickens G, Picchioni M. A systematic review of the evidence of clozapine's anti-aggressive effects. Int J Neuropsychopharmacol. 2012 Oct;15(9):1351-71. doi: 10.1017/S146114571100201X
52. Trifu SC, Tudor A, Radulescu I. Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review). Exp Ther Med. 2020 Oct;20(4):3483-7. doi: 10.3892/etm.2020.8974
53. Makushkina OA, Gurina OI, Vyatkina AI. Study of serotonin, dopamine and hormone profile indicators in individuals with mental disorders with aggressive illegal behavior. Rossiyskiy psikhiatricheskiy zhurnal = Russian Journal of Psychiatry. 2020;(2):46-54. doi: 10.24411/1560-957X-2020-10206 (In Russ.).
Review
For citations:
Makushkina OA, Gurina OI, Golenkova VA. Biological basis of aggressive behavior. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2021;13(5):76-82. (In Russ.) https://doi.org/10.14412/2074-2711-2021-5-76-82
Views:
522
Email this article 