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Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis

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Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes that participates in a range of physiological and pathological processes, including primary hemostasis and coagulation. It also regulates secretion and transport of a variety of molecules, exerts a proinflammatory effect, modulates angiogenesis and smooth muscle mitotic activity, influences atherogenesis. In this review, we discuss the synthesis, secretion, and regulation of the von Willebrand factor within the context of endothelial dysfunction and other common mechanisms that play a significant role in brain tissue damage in cerebrovascular diseases and multiple sclerosis.

About the Authors

I. A. Koltsov
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Ivan Alekseevich Koltsov

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 117997
1, Ostrovityanov St., Build 10, Moscow 117997

M. Yu. Martynov
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 117997
1, Ostrovityanov St., Build 10, Moscow 117997

A. N. Yasamanova
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

1, Ostrovityanov St., Moscow 117997

I. A. Shchukin
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 117997
1, Ostrovityanov St., Build 10, Moscow 117997

M. S. Fidler
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

1, Ostrovityanov St., Moscow 117997

A. N. Boyko
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 117997
1, Ostrovityanov St., Build 10, Moscow 117997


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For citations:

Koltsov I.A., Martynov M.Yu., Yasamanova A.N., Shchukin I.A., Fidler M.S., Boyko A.N. Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(1S):62-68. (In Russ.)

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