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Toll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effects

https://doi.org/10.14412/2074-2711-2021-4-123-129

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Abstract

Toll-like receptors (TLRs) act as receptors for bacterial lipopolysaccharides (LPS) and participate in innate immunity. Excessive TLRs activity leads to chronic inflammation and the development of several comorbid pathologies, including osteoarthritis (OA). Computer analysis of 52,312 publications devoted to TLRs was made to systematically describe the mechanisms of biological action of TLRs and their influence on the OA pathophysiology. In addition, we identified the mechanisms by which slow-acting drugs based on standardized forms of chondroitin sulfate (CS), which have symptom-modifying and structural-modifying effects, can decrease TLRs activity and be used in the treatment of OA. Our conclusions are supported by the results of TLRs chemoreactom analysis, as well as by clinical and experimental data.

About the Authors

I. Yu. Torshin
Institute of pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, National Center for Digital Economy, M.V. Lomonosov Moscow State University
Russian Federation

42, Vavilova St., Build. 2, Moscow 119333; 27, Lomonosovsky Prosp., Build. 1, Moscow 119192.


Competing Interests:

The article expresses the position of the authors, which may differ from that of Sotex PharmFirma. 



O. A. Gromova
Institute of pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, National Center for Digital Economy, M.V. Lomonosov Moscow State University
Russian Federation

Olga Alekseevna Gromova.

42, Vavilova St., Build. 2, Moscow 119333; 27, Lomonosovsky Prosp., Build. 1, Moscow 119192.


Competing Interests:

The article expresses the position of the authors, which may differ from that of Sotex PharmFirma. 



A. M. Lila
V.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation

34A, Kashirskoe Shosse, 115522 Moscow; 2/1, Barrikadnaya St., Build. 1, Moscow 125993.


Competing Interests:

The article expresses the position of the authors, which may differ from that of Sotex PharmFirma. 



L. I. Alekseeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

34A, Kashirskoe Shosse, 115522 Moscow.


Competing Interests:

The article expresses the position of the authors, which may differ from that of Sotex PharmFirma. 



E. A. Taskina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

34A, Kashirskoe Shosse, 115522 Moscow.


Competing Interests:

The article expresses the position of the authors, which may differ from that of Sotex PharmFirma. 



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For citation:


Torshin I.Yu., Gromova O.A., Lila A.M., Alekseeva L.I., Taskina E.A. Toll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effects. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(4):123-129. (In Russ.) https://doi.org/10.14412/2074-2711-2021-4-123-129

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)