nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-4-123-129nnp-1626Research ArticleEXPERIMENTAL STUDIESЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯToll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effectsТолл-подобные рецепторы как компонент патофизиологии остеоартрита: противовоспалительное, анальгетическое и нейропротекторное действиеТоршинИ. Ю.TorshinI. Yu.

119333, Москва, ул. Вавилова, 42, корп. 2; 119192, Москва, Ломоносовский проспект, 27, корп. 1.

42, Vavilova St., Build. 2, Moscow 119333; 27, Lomonosovsky Prosp., Build. 1, Moscow 119192.

ГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна.

119333, Москва, ул. Вавилова, 42, корп. 2; 119192, Москва, Ломоносовский проспект, 27, корп. 1.

Olga Alekseevna Gromova.

42, Vavilova St., Build. 2, Moscow 119333; 27, Lomonosovsky Prosp., Build. 1, Moscow 119192.

unesco.gromova@gmail.comЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1.

34A, Kashirskoe Shosse, 115522 Moscow; 2/1, Barrikadnaya St., Build. 1, Moscow 125993.

АлексееваЛ. И.AlekseevaL. I.

115522, Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, 115522 Moscow.

ТаскинаЕ. А.TaskinaE. A.

115522, Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, 115522 Moscow.

Институт фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наук; Центр хранения и анализа больших данных Национального центра цифровой экономики, Московский государственный университет им. М.В. ЛомоносоваРоссияInstitute of pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, National Center for Digital Economy, M.V. Lomonosov Moscow State UniversityRussian FederationНаучно-исследовательский институт ревматологии им. В.А. Насоновой; Кафедра ревматологии, Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuous Professional Education, Ministry of Health of RussiaRussian FederationНаучно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202114082021134123129Copyright © Torshin I.Y., Gromova O.A., Lila A.M., Alekseeva L.I., Taskina E.A., 20212021Торшин И.Ю., Громова О.А., Лила А.М., Алексеева Л.И., Таскина Е.А.Torshin I.Y., Gromova O.A., Lila A.M., Alekseeva L.I., Taskina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1626

Toll-like receptors (TLRs) act as receptors for bacterial lipopolysaccharides (LPS) and participate in innate immunity. Excessive TLRs activity leads to chronic inflammation and the development of several comorbid pathologies, including osteoarthritis (OA). Computer analysis of 52,312 publications devoted to TLRs was made to systematically describe the mechanisms of biological action of TLRs and their influence on the OA pathophysiology. In addition, we identified the mechanisms by which slow-acting drugs based on standardized forms of chondroitin sulfate (CS), which have symptom-modifying and structural-modifying effects, can decrease TLRs activity and be used in the treatment of OA. Our conclusions are supported by the results of TLRs chemoreactom analysis, as well as by clinical and experimental data.

Толл-подобные рецепторы (Toll-like receptors, TLR) реагируют на бактериальные липополисахариды (ЛПС) и участвуют в формировании врожденного иммунитета. Избыточная активность TLR приводит к хронизации воспаления и к развитию ряда коморбидных патологий, включая остеоартрит (ОА). Компьютерный анализ текстов 52 312 публикаций, посвященных TLR, позволил систематически описать механизмы биологического действия TLR и их влияние на патофизиологию ОА. Выделены механизмы, посредством которых медленнодействующие препараты на основе стандартизированных форм хондроитина сульфата (ХС), обладающие симптом-модифицирующим и структурно-модифицирующим эффектом, могут способствовать снижению активности TLR и использоваться в терапии ОА. Сделанные выводы подтверждаются результатами хемореактомного анализа TLR, а также клиническими и экспериментальными данными.

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The authors declare that there are no conflicts of interest present.