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The mechanisms of reperfusion during in stroke patients treated with intravenous thrombolysis

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Systemic (intravenous) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a proved effective treatment modality in a certain group of patients with ischemic stroke (IS) in the first 4.5 hours after the onset of neurological symptoms. The main mechanism for improving functional outcomes in patients treated with intravenous thrombolysis is reperfusion of an ischemic brain portion. The results of intravenous thrombolytic therapy are shown in 60 IS patients (18 women and 42 men; mean age 61 years). Different mechanisms of reperfusion during systemic thrombolysis, which are not confined to thrombus- or embolus-occluded artery recanalization, but are a portrait of the systemic effect of the thrombolytic drug and include collateral blood flow activation, gradual recanalization, etc.


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For citations:

Domashenko M.A., Maksimova M.Yu., Loskutnikov M.A., Nikonov A.A., Bryukhov V.V., Suslin A.S., Dreval M.V., Konovalov R.N. The mechanisms of reperfusion during in stroke patients treated with intravenous thrombolysis. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(4):53-58. (In Russ.)

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