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Menstrual cycle and gynecologic pathology in menstrual-related migraine

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Migraine is the first most frequent cause of disability among women of reproductive age globally, and up to 60% of patients note the association of headache attacks with menstruation.

Objective: to determine the features of menstrual cycle and gynecologic pathology in women with menstrual-related migraine (MRM).

Patients and methods. A prospective comparative study included 69 women of reproductive age with a migraine diagnosis who did not receive hormonal contraception. Depending on the association of migraine attacks with menstruation (according to headache diaries), the patients were divided into two groups: the 1st group consisted of 44 patients with MRM; group 2 — 25 patients with non-menstrual migraine (without the association of attacks with menstruation).

Results and discussion. Patients with MRM had heavier menstrual bleeding, longer menstruations (more than six days), abnormal menstrual cycle length and regularity, dysmenorrhea. In addition, the obtained data indicate a comorbid estrogen-associated gynecological pathology (endometriosis, adenomyosis, endometrial polyps, myoma) in MRM.

Conclusion. Presumably, the hypothalamic-pituitary-ovarian axis dysfunction plays the leading role in the MRM. It presents with menstrual cycle abnormalities and increased presence of estrogen-associated gynecological pathology, which should be considered during patient evaluation and suggesting recommendations.

About the Authors

E. A. Kiryanova
Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Ekaterina Andreevna Kiryanova.

11, Rossolimo St., Build. 1, Moscow 119021.

Competing Interests:

There are no conflicts of interest.

G. R. Tabeeva
Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

11, Rossolimo St., Build. 1, Moscow 119021.

Competing Interests:

There are no conflicts of interest.


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For citations:

Kiryanova E.A., Tabeeva G.R. Menstrual cycle and gynecologic pathology in menstrual-related migraine. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(4):12-17. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)