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Treatment of antipsychotic-induced parkinsonism in schizophrenic patients

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Antipsychotic-induced parkinsonism (AIP) is one of the prognostically unfavorable complications of psychopharmacotherapy in patients with schizophrenia. Many studies have investigated various drugs that are used to treat this neurological side effect. This review analyzes drugs that are used and may be perspective for the treatment of AIP. We searched for full-text publications in Russian and English in the following databases: E-Library, PubMed, Web of Science, Springer, using keywords and combined word searches over the past decade (2011—2020). The review covers drugs that are promising for the correction of AIP, including anticholinergic drugs; NMDA receptor antagonists; dopamine receptor agonists; selective inhibitors of monoamine oxidase B; catecholamine transferase inhibitors; melatonin preparations; melatonin receptor agonists; benzodiazepines; herbal preparations traditionally used for the prevention and correction of extrapyramidal syndrome of various etiologies. Currently, a small number of medications are used in clinical practice for the treatment of AIP. However, not all of them are registered in the Russian Federation. Along with the differences in the mechanisms of AIP pathogenesis in specific patients, the limited choice of AIP treatments makes it difficult to solve the problem of adverse neurological complications of psychopharmacotherapy in schizophrenia.

About the Authors

E. E. Vaiman
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia
Russian Federation

3, Bekhterev St., Saint Petersburg 192019.

Competing Interests:

There are no conflicts of interest.

N. A. Shnayder
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia; V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

3, Bekhterev St., Saint Petersburg 192019; 1, Partisan Zheleznyak St., Krasnoyarsk 660022.

Competing Interests:

There are no conflicts of interest.

N. G. Neznanov
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia
Russian Federation

3, Bekhterev St., Saint Petersburg 192019.

Competing Interests:

There are no conflicts of interest.

R. F. Nasyrova
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia
Russian Federation

3, Bekhterev St., Saint Petersburg 192019.

Competing Interests:

There are no conflicts of interest.


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For citations:

Vaiman E.E., Shnayder N.A., Neznanov N.G., Nasyrova R.F. Treatment of antipsychotic-induced parkinsonism in schizophrenic patients. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(4):4-11. (In Russ.)

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ISSN 2074-2711 (Print)
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