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Results of Expert Council meeting on modern principles of treatment optimization in patients with relapsing-remitting multiple sclerosis using anti-CD20 monoclonal antibody

https://doi.org/10.14412/2074-2711-2021-3-131-136

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Abstract

The article presents the results of the discussion of the use of anti-B-cell therapy in multiple sclerosis (MS). These cells play a significant role in immunoregulation in MS, not only by producing antibodies to myelin antigens after transformation into plasma cells, but also by presenting the antigen to T cells, producing activation cytokines, and forming laminar follicles. The article provides an expert consensus statement on different drugs of this class in the MS treatment. In addition, the possibilities of determining the disease prognosis for the initially correct treatment choice are highlighted. Undoubtedly, there is a need for confirmation of the MS diagnosis, possible stratification of patients into different risk groups, and evaluation of the response to therapy. Potential additional research methods included evoked potentials and optical coherence tomography, baseline vitamin D3 level as a prognostic marker of the disease course, neurofilament levels in serum and cerebrospinal fluid to confirm neuron damage. However, it takes much time to study, determine the methodology, reference values, and develop a single standard approach to identify and implement a biomarker, which should then be implemented in routine clinical practice.

About the Authors

A. N. Boyko
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Institute of clinical neurology, Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Aleksey Nikolaevich Boyko

Department of neurology, neurosurgery, and medical genetics N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

1, Ostrovityanov St., Moscow 117997,

1, Ostrovityanov St., Build 10, Moscow 117997



N. V. Khachanova
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Department of neurology, neurosurgery, and medical genetics N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

1, Ostrovityanov St., Moscow 117997



D. S. Korobko
Regional Center of Multiple Sclerosis and other Autoimmune Diseases of Nervous system, Novosibirsk State regional clinical hospital
Russian Federation

130, Nemirovich-Danchenko St., Novosibirsk 630087



D. S. Kasatkin
Yaroslavl State Medical University, Ministry of Health of Russia
Russian Federation

5, Revolutsionnaya St., Yaroslavl 150000



Ya. V. Vlasov
Samara State Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology and Neurosurgery

89, Chapaevskaya St., Samara 443099



E. P. Evdoshenko
Saint Petersburg City Center for Multiple Sclerosis and other Autoimmune Diseases, City Clinical Hospital Thirty-One
Russian Federation

3, Dynamo Pr., Saint Petersburg 197110



E. V. Popova
City Clinical Hospital Twenty-Four, Moscow Healthcare Department
Russian Federation

10, Pistsovaya St., Moscow 127015



K. Z. Bakhtiyarova
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

3, Lenina St., Ufa 450008



S. A. Sivertseva
Tyumen Regional Center for Multiple Sclerosis
Russian Federation

8/1, Yuri Semovsky St., Tyumen 625032



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For citation:


Boyko A.N., Khachanova N.V., Korobko D.S., Kasatkin D.S., Vlasov Y.V., Evdoshenko E.P., Popova E.V., Bakhtiyarova K.Z., Sivertseva S.A. Results of Expert Council meeting on modern principles of treatment optimization in patients with relapsing-remitting multiple sclerosis using anti-CD20 monoclonal antibody. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(3):131-136. (In Russ.) https://doi.org/10.14412/2074-2711-2021-3-131-136

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)