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Central pontine myelinolysis in the presence of SARS-CoV-2 infection (clinical observations)

https://doi.org/10.14412/2074-2711-2021-2-91-96

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Abstract

 Osmotic demyelinating syndrome (ODS) is a severe complication that occurs due to rapid correction of hyponatremia. Central  pontine myelinolysis (CPM), in which a focus of demyelination  occurs in the pontine region, and extrapontine myelinolysis (EPM),  in which foci of demyelination appear in the white matter of the  cerebral hemispheres, can be distinguished as a part of this  syndrome. We describe two clinical cases of CPM that developed due to hyponatremia and hypokalemia in patients with SARS-CoV-2 infection (COVID-19). Differential diagnosis included acute  disseminated encephalomyelitis, infectious encephalitis, and brain  tumor. In both cases, a significant recovery of the lost functions was noted. The pathogenetic mechanisms of CPM development in  patients with COVID-19 are discussed. ODS development in COVID- 19 necessitates strict control and correction of electrolyte  disturbances in this category of patients in accordance with existing  recommendations, which can reduce the risk of CPM. 

About the Authors

O. N. Voskresenskaya
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



A. A. Kovalenko
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



E. B. Nadbitova
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



V. V. Grinyuk
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



A. V. Klimanov
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



Yu. M. Shor
A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

 11, Rossolimo Str., Build. 1, Moscow 119021, Russia 



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For citation:


Voskresenskaya O.N., Kovalenko A.A., Nadbitova E.B., Grinyuk V.V., Klimanov A.V., Shor Yu.M. Central pontine myelinolysis in the presence of SARS-CoV-2 infection (clinical observations). Neurology, Neuropsychiatry, Psychosomatics. 2021;13(2):91-96. (In Russ.) https://doi.org/10.14412/2074-2711-2021-2-91-96

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)