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Pain reliever combinations in treatment of patients with acute musculoskeletal back pain

https://doi.org/10.14412/2074-2711-2021-2-73-78

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Abstract

Objective: to compare the clinical efficacy of complex therapy, including a combination of a nonsteroidal anti-inflammatory drug (NSAID) with a muscle relaxant and B vitamins in acute musculoskeletal back pain (MSBP).

Patients and methods. We enrolled 66 patients with acute MSBP, 27 men and 39 women, mean age – 52.8 [29.4; 68.8] years. All patients had different pain localization: 36 (54.5%) – lumbodynia, 22 (33.3%) – cervicodynia, 8 (12.2%) –  thoracodynia. Visual analog scale (VAS) was used to assess pain intensity. Patients in the 1st group (n=32) were prescribed with complex therapy, including Russian drugs meloxicam (Amelotex 15 mg per day), tolperison (Kalmirex), and a neurotropic  multivitamin supplement Compligam B. Patients in the 2nd  group (n=34) received a combination of only two of the three drugs. We assessed pain intensity with VAS, disability duration, and treatment effectiveness from the doctor's and patient's perspectives. 

Results and discussion. After 5 days of treatment, pain regression was noted in both groups; pain reduction by 50% or more from the initial level prevailed in 1st group (p=0.03). A rapid NSAID dose decrease prevailed in the 1st group; from the 5th to the 10th day, all patients switched to the 7.5 mg meloxicam dose. The duration of temporary disability in the 1st group was less than 7 days, in the 2nd group – 9 days (p<0.05). Complex therapy in group 1 was more effective than therapy in group 2, according to doctors and patients (p<0.05). 

Conclusion. The combination of NSAID with a muscle relaxant and B vitamins can reduce the duration and the incidence of  adverse drug reactions of NSAID therapy, and reduce the  duration of temporary disability. 

About the Authors

R. V. Gorenkov
N.A. Semashko National Research Institute of Public Health; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

12, Vorontsovo Pole St., Build. 1, Moscow 105064, Russia;

8, Trubetskaya, Build. 2, Moscow 119991, Russia 



M. N. Dadasheva
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

 61/2, Shchepkin St., Build. 1, Moscow 129110, Russia 



D. I. Lebedeva
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation

 54, Odesskaya St., Tyumen 625048, Russia 



I. V. Choi
Central Clinical Hospital of the Russian Academy of Sciences
Russian Federation

 1A, Litovskiy Blvd., Moscow 117593, Russia 



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For citation:


Gorenkov R.V., Dadasheva M.N., Lebedeva D.I., Choi I.V. Pain reliever combinations in treatment of patients with acute musculoskeletal back pain. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(2):73-78. (In Russ.) https://doi.org/10.14412/2074-2711-2021-2-73-78

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)