Nociception: the roles of vitamin D
https://doi.org/10.14412/2074-2711-2021-1-145-153
Abstract
Objective: to carry out a systematic computer-assisted analysis of scientific literature on on the relationships between the effects of vitamin and nociception (including the impact of vitamin D deficiency on the development of pain syndrome.
Material and methods. For the query “(pain OR nociception) AND (vitamin D OR cholecalciferol OR VITD OR CALCITRIOL OR HYDROXYVITAMIN OR DIHYDROXYVITAMIN OR ALPHACALCIDOL)", 2318 references, including 77 references on alpha-calcidol, were found in the biomedical publications database PubMed. The computer-assisted analysis of this array of publications was carried out using the current big data analysis methods developed within the topological and metric approaches to recognition/classification problems.
Result and discussion. A systematic computer-assisted text analysis of 2318 studies on the relationships between nociception and vitamin D showed that the analgesic effects of the vitamin are by anti-inflammatory action and the regulation of serotonergic, dopaminergic, and opioidergic neurotransmission. The lower blood levels of the major vitamin D metabolite 25 (OH)D is a risk factor for decreased pain threshold in myalgia, fibromyalgia, arthralgia, dorsalgia, and a number of neuralgias.
Conclusion. In patients with impaired renal conversion of active vitamin D metabolites (especially in the elderly), the efficacy of cholecalciferol-based drugs is reduced, which makes it necessary to use the active forms of vitamin D.
About the Authors
O. A. Gromova
Federal Research Center for Informatics and Management, Russian Academy of Sciences; M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
Olga Alekseevna Gromova
Institute of Pharmacoinformatics
44, Vavilov St., Build. 2, Moscow 119333
Center for Big Data Storage and Analysis, National Center for Digital Economy
1, Leninskie Gory, Moscow 119234
I. Yu. Torshin
Federal Research Center for Informatics and Management, Russian Academy of Sciences; M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
Institute of Pharmacoinformatics
44, Vavilov St., Build. 2, Moscow 119333
Center for Big Data Storage and Analysis, National Center for Digital Economy
1, Leninskie Gory, Moscow 119234
M. V. Putilina
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
1, Ostrovityanov St., Moscow 117997
Russian Federation
1, Ostrovityanov St., Moscow 117997
I. S. Sardaryan
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
2, Litovskaya St., Saint Petersburg 194100
Russian Federation
2, Litovskaya St., Saint Petersburg 194100
L. E. Fedotova
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
8, Sheremetesky Prospect, Ivanovo 153012
O. A. Limanova
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetesky Prospect, Ivanovo 153012
Russian Federation
8, Sheremetesky Prospect, Ivanovo 153012
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Review
Supporting agencies: The investigation has been conducted under Russian Foundation for Basic Research / Russian Science Foundation Grants No. 19-07-00356 and No. 20-07-00537.
For citations:
Gromova O.A., Torshin I.Yu., Putilina M.V., Sardaryan I.S., Fedotova L.E., Limanova O.A. Nociception: the roles of vitamin D. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(1):145-153. (In Russ.) https://doi.org/10.14412/2074-2711-2021-1-145-153
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