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COVID-19 and mental health: challenges and first conclusions

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Under the conditions of the COVID-19 pandemic, a rapid change in the epidemiological situation, and introduced quarantine measures, there are conditions for a sharp deterioration in the mental health of a wide range of people. There are specific stressors that negatively affect mental health; there are population groups that are more vulnerable to psychological stress and the development of pathological psychological defense reactions; there is a sharp rise in the number of cases of heterogeneous mental disorders (depression, anxiety, post-traumatic stress disorders, etc.) among the population and healthcare workers in the foci of infection. The manifestation or exacerbation of mental illness in turn contributes to the spread of viral infection and is associated with a more frequent development of somatic complications and a poor prognosis. The practical problem is to choose effective psychopharmacological agents for the relief and treatment of mental disorders, by taking into account the need to combine the agents with antiviral drugs in somatically weakened COVID-19 patients.

About the Authors

V. E. Medvedev
Medical Institute, Peoples' Friendship University of Russia (RUDN University)
Russian Federation

Vladimir Ernstovich Medvedev

Department of Psychiatry, Psychotherapy, and Psychosomatic Pathology, Faculty of Continuing Medical Education

21, Miklukho-Maklai St., Build. 3, Moscow 117198

O. A. Dogotar
Accreditation and Simulation Training Center, Medical Institute, Peoples' Friendship University of Russia (RUDN University)
Russian Federation

10/2, Miklukho-Maklai St., Moscow 117198


1. Bertelli MO, Scuticchio D, Bianco А, et al. A proposal for responding to the outbreak of COVID-19 and associated mental distress factors in people with intellectual disabilities and autism spectrum disorders with high to very high care needs. 2020. Available from: (In Russ.)

2. Qiu J, Shen B, Zhao M, et al. A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations. Gen Psychiatry. 2020;33:e100213. doi: 10.1136/gpsych-2020-100213corr1

3. Brooks SK, Webster RK, Smith LE, et al. The Psychological Impact of Quarantine and How to Reduce It: Rapid Review of the Evidence. Lancet. 2020 Mar 14;395(10227):912-20. doi: 10.1016/S0140-6736(20)30460-8. Epub 2020 Feb 26.

4. World Health Organization. Mental Health and Psychosocial Considerations During COVID-19 Outbreak. 2020. Available from:

5. Mental Health UK. Managing your mental health during the coronavirus outbreak. Accessed March 31, 2020. Available from:

6. Sorokin MYu, Kas'yanov ED, Rukavishnikov GV, et al. The structure of anxious experiences associated with the spread of COVID-19: data from an online survey. Vestnik RGMU. 2020;(3). doi: 10.24075/vrgmu.2020.030 (In Russ.)

7. Agamamedova IN, Bannikov GS, Keshchyan KL, et al. Psikhicheskiye reaktsii i narusheniya povedeniya u lits s COVID-19. Informatsionnoye pis'mo [Mental reactions and behavioral disorders in persons with COVID-19. Information mail]. Moscow; 2020. 9 p. Available from: (In Russ.)

8. Lai J, Ma S, Wang Y, et al. Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. JAMA Netw Open. 2020 Mar 2;3(3):e203976. doi: 10.1001/jamanetworkopen.2020.3976

9. London RT. Is COVIDE19 leading to a mental illness pandemic? Presented by ID PracEtitioner in MDedge Infectious disease [published online March 25, 2020]. Available from: (accessed April 4, 2020).

10. Schwartz BJ. New APA survey on public anxiety over COVIDE19. High Anxiety in America Over COVID-19. Medscape. Mar 28, 2020.

11. Statement on the second meeting of the International Health Regulations Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). World Health Organization (WHO), 2020. Available from: (assessed Feb 15, 2020).

12. Goldberg JF. Psychiatry's niche role in the COVIDE19 pandemic. J Clin Psychiatry. 2020 Apr 7;81(3):20com13363. doi: 10.4088/JCP.20com13363

13. Yao H, Chen JH, Xu YF. Patients with mental health disorders in the COVID-19 epidemic. Lancet Psychiatry. 2020 Apr;7(4):e21. doi: 10.1016/S2215-0366(20)30090-0

14. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020 Jun;92(6):552-5. doi: 10.1002/jmv.25728. Epub 2020 Mar 11.

15. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033-4. doi: 10.1016/S0140-6736(20)30628-0

16. Medvedev VE, Korovyakova EA, Frolova VI, Gushanskaya EV. Antidepressant therapy in patients with cardiovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):131-40. doi: 10.14412/2074-2711-2019-1-131-140 (In Russ.).

17. Steptoe A, Shankar A, Demakakos P, et al. Social isolation, loneliness, and all cause mortality in older men and women. Proc Natl Acad Sci USA. 2013 Apr 9;110(15):5797-801. doi: 10.1073/pnas.1219686110. Epub 2013 Mar 25.

18. China Newsweek. Collective infections of coronavirus among 50 patients and 30 health workers in one psychiatric hospital in Wuhan. Shanghai Obs. 2020. Available from: (accessed Feb 17, 2020).

19. Fagiolini A, Cuomo A, Frank E. COVID-19 diary from a psychiatry department in Italy. J Clin Psychiatry. 2020 Mar 31;81(3):20com13357. doi: 10.4088/JCP.20com13357

20. Garriga M, Agasi I, Fedida E, et al. The role of Mental Health Home Hospitalization Care during the COVID-19 pandemic. Acta Psychiatrica Scandinavica. 2020 May;141(5):479-80. doi: 10.1111/acps.13173

21. Kim MJ. «It was a medical disaster»: The psychiatric ward that saw 100 patients diagnosed with new coronavirus. Independent [published online March 1, 2020]. Available from:

22. Dong L, Bouey J. Public Mental Health Crisis during COVID-19 Pandemic, China. Emerg Infect Dis. 2020 Jul;26(7):1616-8. doi: 10.3201/eid2607.200407. Epub 2020 Jun 21.

23. Yang Y, Li W, Zhang Q, et al. Mental health services for older adults in China during the COVID-19 outbreak. Lancet Psychiatry. 2020 Apr;7(4):e19. doi: 10.1016/S2215-0366(20)30079-1. Epub 2020 Feb 19.

24. Courtet P, Olie E, Debien C, Vaiva G. Keep socially (but not physically) connected and carry on: preventing suicide in the age of COVID-19. J Clin Psychiatry. 2020 Apr 14;81(3):20com13370. doi: 10.4088/JCP.20com13370

25. Goyal K, Chauhan P, Chhikara K, et al. Fear of COVID 2019: first suicidal case in India! Asian J Psychiatr. 2020 Mar;49:101989. doi: 10.1016/j.ajp.2020.101989. Epub 2020 Feb 27.

26. Tubbs AS, Perlis ML, Basner M, et al. Relationship of nocturnal wakefulness to suicide risk across months and methods of suicide. J Clin Psychiatry. 2020 Feb 25;81(2):19m12964. doi: 10.4088/JCP.19m12964

27. Luhby T. CNN, Published online April 16, 2020. Available from:

28. Schwartz BJ. New Poll: COVID-19 Impacting Mental Well-Being: Americans Feeling Anxious, Especially for Loved Ones. APA News releases. March 25, 2020. Available from:

29. Galea S, Merchant RM, Lurie N. The Mental Health Consequences of COVID-19 and Physical Distancing: The Need for Prevention and Early Intervention. JAMA Intern Med. 2020 Jun 1;180(6):817-8. doi: 10.1001/jamainternmed.2020.1562

30. Rossi R, Socci V, Talevi D, et al. COVID-19 pandemic and lockdown measures impact on mental health among the general population in Italy. An N=18147 web-based survey. 2020. medRxiv preprint. doi: 10.1101/2020.04.09.20057802

31. Novel coronavirus (2019-nCoV): strategic preparedness and response plan Feb 3, 2020. World Health Organization, 2019 [cited 2020 Feb 7]. Available from:

32. Li W, Yang Y, Liu ZH, et al. Progression of Mental Health Services during the COVID-19 Outbreak in China. Int J Biol Sci. 2020 Mar 15;16(10):1732-8. doi: 10.7150/ijbs.45120. eCollection 2020.

33. Rossi R, Socci V, Pacitti F, et al. Mental health outcomes among front and second line health workers associated with the COVID-19 pandemic in Italy. medRxiv preprint. 2020.04.16.20067801. doi: 10.1101/2020.04.16.20067801

34. Mosolov SN. Current challenges for mental health services in relation to the COVID-19 pandemic. Sovremennaya terapiya psikhicheskikh rasstroystv. 2020;(2). doi: 10.21265/PSYPH.2020.53.59536 (In Russ.).

35. Doarn CR. Telemedicine and psychiatry: a natural match. mHealth. 2018 Dec 19;4:60. doi: 10.21037/mhealth.2018.12.04. eCollection 2018.

36. Duan L, Zhu G. Psychological interventions for people affected by the COVID-19 epidemic. Lancet Psychiatry. 2020 Apr;7(4):300-2. doi: 10.1016/S2215-0366(20)30073-0. Epub 2020 Feb 19.

37. Liu S, Yang L, Zhang C, et al. Online mental health services in China during the COVID-19 outbreak. Lancet Psychiatry. 2020 Apr;7(4):e17-e18. doi: 10.1016/S2215- 0366(20)30077-8. Epub 2020 Feb 19.

38. American Psychiatric Association (APA). Telepsychiatry Practice Guidelines. Available from: (accessed April, 23 2020).

39. Zhou X. Psychological crisis interventions in Sichuan Province during the 2019 novel coronavirus outbreak. Psychiatry Res. 2020 Feb 26;286:112895. doi: 10.1016/j.psychres.2020.112895

40. The State Council of China. A notification to setup nationwide psychological assistance hotlines against the 2019-nCoV outbreak. Published February 2, 2020. Available from: (accessed March 3, 2020).

41. Liu N, Zhang F, Wei C, et al. Prevalence and predictors of PTSS during COVID-19 Outbreak in China Hardest-hit Areas: Gender differences matter. Psychiatry Res. 2020 May;287:112921. doi: 10.1016/j.psychres.2020.112921. Epub 2020 Mar 16.

42. Sohn E. COVID-19: National PsychiatristRun Hotline Offers Docs Emotional PPE. Medscape Medical News. Published online April 24, 2020. Available from:

43. Medvedev VE, Kardashyan RA, Frolova VI, et al. Investigation of the efficiency of various antidepressant replacement regimens in the development of SSRI-induced apathy syndrome. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2020;12(2):48-56. doi: 10.14412/2074-2711-2020-2-48-56 (In Russ.).

44. Medvedev VE, Ter-Israyelyan AYu, Frolova VI, et al. Optimization of therapy for mental disorders with a multisyndromic clinical picture. Psikhiatriya i psikhofarmakoterapiya im. P.B. Gannushkina. 2020;(1):23-7 (In Russ.).

45. Medvedev VE. Effectiveness and tolerability of modern antidepressants: results of network meta-analyzes and Russian experience. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018;118(11):109-17. doi: 10.17116/jnevro2018118111109 (In Russ.).

46. Medvedev VE. Depressive disorders. In: Putevoditel' vrachebnykh naznacheniy. Sovremennoye rukovodstvo dlya praktikuyushchikh vrachey [Guide to medical appointments. A modern guide for medical practitioners]. Vol. 6. Ed. A.I. Martynov. Moscow: Bionika Media; 2018. P. 57-69 (In Russ.).

47. Mosolov SN. Mental health problems in the context of the COVID-19 pandemic. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2020;120(5):7-15. doi: 10.17116/jnevro20201200517 (In Russ.).

48. Kostyukova EG, Malin DI, Mosolov SN, Tsukarzi EE. Lekarstvennaya terapiya lits s psikhicheskimi rasstroystvami, zabolevshikh koronavirusnoy infektsiyey (COVID-19). Informatsionnoye pis'mo [Drug therapy for people with mental disorders who contract coronavirus infection (COVID-19). Information mail]. Moscow; 2020. 14 p. Available from: (In Russ.).

49. FDA/U.S. Food and Drug Administration. 19.12.2019. Available from:

50. Chan HY, Lai CL, Lin YC, Hsu CC. Is Antipsychotic Treatment Associated With Risk of Pneumonia in People With Serious Mental Illness? The Roles of Severity of Psychiatric Symptoms and Global Functioning. J Clin Psychopharmacol. Sep/Oct 2019;39(5):434-40. doi: 10.1097/JCP.0000000000001090

51. Knol W, van Marum RJ, Jansen PA, et al. Antipsychotic drug use and risk of pneumonia in elderly people. J Am Geriatr Soc. 2008 Apr;56(4):661-6. doi: 10.1111/j.1532-5415.2007.01625.x. Epub 2008 Feb 7.

52. Stein DJ. Pharmacotherapy of adjustment disorder: a review. World J Biol Psychiatry. 2018;19(suppl 1):46-52. doi: 10.1080/15622975.2018.1492736

53. Medvedev VE. Alimemazine in psychiatry and psychosomatics. Psikhiatriya i psikhofarmakoterapiya im. P.B. Gannushkina. 2018;20(3-4):26-33 (In Russ.).

54. Mosolov SN, Malin DI, Ryvkin PV, Sychev DA. Drug interactions of drugs used in psychiatric practice. Sovremennaya terapiya psikhicheskikh rasstroystv. 2019;(1):1-35. doi: 10.21265/PSYPH.2019.50.40828 (In Russ.).

55. COVID-19 Drug Interactions. The Liverpool Drug Interaction Group. Department of Pharmacology at the University of Liverpool. Available from: (accessed April 23, 2020).

56. FDA / U.S. Food and Drug Administration. 29.07.2013. Drug Safety Communication: FDA approves label changes for antimalarial drug mefloquine hydrochloride due to risk of serious psychiatric and nerve side effects. Available from:

57. Goodlet KJ, Zmarlicka MT, Peckham A. Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs. CNS Spectrums. 2019 Jun;24(3):287-312. doi: 10.1017/S109285291800113X. Epub 2018 Oct 8.

58. Wynn GH, Oesterheld IR, Cozza KL, Armstrong SC. Clinical Manual of Psychotropic Drug Interaction. Principles for medical practice. Washington DC: APP; 2009. 594 p.


For citations:

Medvedev V.E., Dogotar O.A. COVID-19 and mental health: challenges and first conclusions. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(6):4-10. (In Russ.)

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ISSN 2074-2711 (Print)
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