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NMDA receptor antagonists in the treatment of neurological diseases

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The paper reviews clinical trials evaluating the efficacy of N-methyl-D-aspartate (NMDA) receptor antagonists used to treat various neurological diseases: neurodegenerative dementias, vascular cognitive disorders, including post-stroke cognitive impairment. It discusses the possibility of treating cognitive disorders with NMDA receptor antagonists in Parkinson's disease, traumatic brain injury, and some other diseases, as well as the potential possibilities of using drugs of this pharmacotherapeutic group in childhood. The paper describes a clinical case illustrating the use of akatinol memantine in a child with a delay in speech and mental development in the presence of fetal alcohol syndrome. The possibilities of using akatinol memantine in the treatment of childhood cognitive impairments are sure to be of particular interest; however, in view of the small amount of data, this aspect requires further clinical trials.

About the Author

I. S. Preobrazhenskaya
N.V. Sklifosovsky Institute of Clinical Medicine I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Irina S. Preobrazhenskaya

Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Build. 1, Moscow 119021


1. Preobrazhenskaya IS. Some aspects of the background symptomatic treatment of cognitive impairment of various severity types. Meditsinskiy sovet. 2013;(12):50-4. doi: 10.21518/2079-701X-2013-12-50-54 (In Russ.).

2. Preobrazhenskaya IS, Korshunov AM. Programmed cell death. Nevrologicheskiy zhurnal. 1998;(1):40-6 (In Russ.).

3. Kishi T, Matsunaga S, Oya K, et al. Memantine for Alzheimer's Disease: An Updated Systematic Review and Metaanalysis. J Alzheimers Dis. 2017;60(2):401-25. doi: 10.3233/JAD-170424

4. Kodis EJ, Choi S, Swanson E, et al. N-Methyl-D-Aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease. Alzheimers Dement. 2018 Oct;14(10):1302-12. doi: 10.1016/j.jalz.2018.05.017. Epub 2018 Jul 4.

5. Folch J, Busquets O, Ettcheto M, et al. Memantine for the Treatment of Dementia: A Review on its Current and Future Applications. J Alzheimers Dis. 2018;62(3):1223-40. doi: 10.3233/JAD-170672

6. Parfenov VA, Neverovsky DV. Outpatient management of patients with dyscirculatory encephalopathy. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;(1):37-42. doi: 10.14412/2074-2711-2015-1-37-42 (In Russ.).

7. Preobrazhenskaya IS. NMDA receptor antagonists in the treatment of patients with vascular cognitive imprairments. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2014;(2S):69- 74. doi: 10.14412/2074-2711-2014-2S-69-74 (In Russ.).

8. Yahno NN, Preobrazhenskaya IS, Zakharov VV, Mkhitaryan EA. The effectiveness of memantine administraton in patients with non-dementia cognitive impairment. The results of a multicentre clinical follow-up study. Rossiyskiy nevrologicheskiy zhurnal = Russian Neurological Journal. 2019;(3):37-44. doi: 10.30629/2658-7947-2019-24-3-37-44 (In Russ.).

9. Inoue Y, Ueda M, Masuda T, et al. Memantine, a Noncompetitive N-Methyl-DAspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression. Mol Neurobiol. 2019;56:8573-88. doi: 10.1007/s12035-019-01678-7

10. Seyedsaadat SM, Kalmes DF. Memantine for the treatment of ischemic stroke: experimental benefits and clinical lack of studies. Rev Neurosci. 2019 Jan 28;30(2):203-20. doi: 10.1515/revneuro-2018-0025

11. Berthier ML, Green C, Lara JP, et al. Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia. Ann Neurol. 2009 May;65(5):577-85. doi: 10.1002/ana.21597

12. Jin BR, Liu HY. Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis. Neur Regenerat Res. 2019;14(5):805-16. doi: 10.4103/1673-5374.249228

13. Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicenter trial. Lancet Neurol. 2009 Jul;8(7):613-8. doi: 10.1016/S1474-4422(09)70146-2. Epub 2009 Jun 10.

14. Johansson C, Ballard C, Hansson O, et al. Efficacy of memantine in PDD and DLB: an extension study including washout and openlabel treatment. Int J Geriatr Psychiatry. 2011 Feb;26(2):206-13. doi: 10.1002/gps.2516

15. Leroi I, Overshott R, Byrne EJ, et al. Randomized controlled trial of memantine in dementia associated with Parkinson's disease. Mov Disord. 2009 Jun 15;24(8):1217-21. doi: 10.1002/mds.22495

16. Ondo WG, Shinawi L, Davidson A, et al. Memantine for non-motor features of Parkinson's disease: a double-blind placebo controlled exploratory pilot trial. Parkinsonism Relat Disord. 2011;17:156-9. doi: 10.1016/j.parkreldis.2010.12.003

17. Stubendorff K, Larsson V, Ballard C, et al. Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study. BMJ Open. 2014 Jul 3;4(7):e005158. doi: 10.1136/bmjopen-2014-005158

18. Mokhtari M, Nayeb-Aghaei H, Kouchek M, et al. Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients with Moderate Traumatic Brain Injury. J Clin Pharmacol. 2018 Jan;58(1):42-7. doi: 10.1002/jcph.980. Epub 2017 Jul 19.

19. Ramaswamy S, Madabushi J, Hunziker J, et al. An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. J Aging Res. 2015;2015:934162. doi: 10.1155/2015/934162. Epub 2015 May 12.

20. Zheng W, Li XH, Yang XH, et al. Adjunctive memantine for schizophrenia: a meta-analysis of randomized, double-blind, placebo-controlled trials. Psychol Med. 2018 Jan;48(1):72-81. doi: 10.1017/S0033291717001271. Epub 2017 May 22.

21. Krishnan-Sarin S, O'Malley SS, Franco N, et al. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology. 2020 Jan;45(2):319-26. doi: 10.1038/s41386-019-0536-z. Epub 2019 Oct 7.

22. Aman MG, Findling RL, Hardan AY, et al. Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension. J Child Adolesc Psychopharmacol. 2017;27(5):403-12. doi: 10.1089/cap.2015.0146

For citation:

Preobrazhenskaya I.S. NMDA receptor antagonists in the treatment of neurological diseases. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(5):71-77. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)