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The use of perampanel in drug-resistant focal epilepsy: its effect on sleep

https://doi.org/10.14412/2074-2711-2020-6-49-53

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Abstract

Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia.

Objective: to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED.

Patients and methods. The investigation enrolled 12 patients (4 men and 8 women) aged 21 to 49 years with drug-resistant epilepsy treated with several AEDs, who had initiated therapy with PER as an additional AED. PSG study and questioning survey were done before and 1 month after initiation of PER therapy.

Results and discussion. After one month of PER therapy, there was an increase in the quality of night sleep in 5 cases and a reduction in daytime sleepiness in 6 cases. The PSG pattern was stable in 3 patients, worsened in 1, and improved in 8.

Conclusion. The preliminary results suggest that PER therapy improves night sleep quality and reduces daytime sleepiness in about half of the cases, as evidenced by the improved PSG pattern in 67% of patients.

About the Authors

A. A. Filin
L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Healthcare Department
Russian Federation

Aleksandr Aleksandrovich Filin

18A, Zagorodnoe Highway, Build. 2, Moscow 117152



M. V. Tardov
L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Healthcare Department
Russian Federation

18A, Zagorodnoe Highway, Build. 2, Moscow 117152



N. L. Kunelskaya
L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Healthcare Department; N.I. Pirogov Russian Research Medical University, Ministry of Health of Russia
Russian Federation

Acad. B.S. Preobrazhensky Department of Otorhinolaryngology, Faculty of General Medicine

18A, Zagorodnoe Highway, Build. 2, Moscow 117152, 

1, Ostrovityanov St., Moscow 117997, Russia



P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases

20, Delegatskaya St., Build. 1, Moscow 127473



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For citation:


Filin A.A., Tardov M.V., Kunelskaya N.L., Vlasov P.N. The use of perampanel in drug-resistant focal epilepsy: its effect on sleep. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(6):49-53. (In Russ.) https://doi.org/10.14412/2074-2711-2020-6-49-53

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)