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Efficacy of valdoxan in the prevention and treatment of post-stroke depression

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The efficacy of valdoxan (agomelatine) used to prevent and treat post-stroke depression was analyzed. The study enrolled 49 patients (21 men and 28 women; mean age 61+5.5years) in the acute period of ischemic stroke in different vascular basins (a study group). A control group included 50 patients (24 men and 26 women; mean age 64+4.8 years) who were comparable with the study group of patients and who did not receive valdoxan. The duration of a follow-up was 6 months. During valdoxan therapy, there were better changes in recovery with a rapider regression of neurological disorders in patients with moderate stroke as compared with the control group (according to the National Institute of Health Stroke Scale (NIHSS). The administration of valdoxan prevents depression, sleep disorders, pain syndromes, and cognitive impairments in the acute and early rehabilitation period of stroke.


1. <div><p>Starkstein S.E, Mizrahi R., Power B.D. Antidepressant therapy in post-stroke depression. Expert opin Pharmacother 2008;9(8):1291—8.</p><p>Каннер А.М. Депрессия при неврологических заболеваниях. М.:Литтерра, 2007;159.</p><p>Терапия антидепрессантами и другие методы лечения депрессивных расстройств. Доклад рабочей группы CINP на основе обзора доказательных данных. М., 2008;150.</p><p>Robinson R.G., Jorge R.E., Moser D.J. et al. Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA. 2008;28;299(20):2391-400.</p><p>Almeida O.P., Waterrrus A., Hankey G.J. Preventing depression after stroke: Results from a randomized placebo-controlled trial. J Clin Psychiatry 2006;67(7):1104—9.</p><p>De Klerk O.L., Bosker J.F., Willemsen A.T.M. et al. Chronic stress and antidepressant treat ment have opposite effects on P-glycoprotein at the blood-brain barrier an experimental PET study. J Psychopharmacol 2010;24:1237-42.</p><p>Hama S., Yamashita H., Yamawaki S. et al. Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response. Phychogeriatrics 2011;11:68-76.</p></div><br />


For citations:

Khasanova D.R., Zhitkova Yu.V., Safiullina A.A. Efficacy of valdoxan in the prevention and treatment of post-stroke depression. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(3):48-53. (In Russ.)

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ISSN 2074-2711 (Print)
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