Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Cognitive impairments in young people with opioid addiction and their correction

https://doi.org/10.14412/2074-2711-2012-402

Abstract

Objective: to evaluate cognitive functions and drug correction of identified impairments in heroin users. Patients and methods. Thirty-two patients (7 women and 25 men) aged 18 to 45 years who had used heroin for 1—3 years were examined using the mini-mental state examination (MMSE), the techniques of «memorizing words» and «excluding words», the tests of «information-memory-concentration», quantitative assessment of clock drawing, and the frontal assessment battery. The detected cognitive impairments were corrected with the standardized Ginkgo Biloba extract (EGb 761 ®, Tanakan ®). Results. Cognitive impairments were found in all the patients: moderate cognitive disorders in 68.8% and mild dementia in 31.2%; thinking disorders were most noticeable; decreased attention, frontal lobe dysfunction, and visual spatial impairments were detectable. After a course of therapy with tanakan (120—240 g/day according to the degree of cognitive impairments for 3 months), there was a significant improvement in MMSE scores, thought, concentration, memory; however, they failed to achieve the scores in the control group consisting of 10 apparently healthy individuals of the same age and sex.

References

1. <div><p>Кошкина Е.А., Киржанова В.В., Вышинский К.В. и др. Социально-дермографические и поведенческие особенности потребителей наркотиков и оценка их численности в горосом 2011;3:8-13.</p><p>Тювина Н.А., Балабанова В.В., Гончарова Е.М. Опыт применения сульпирида при эндогенных депрессивно-ипохондах Северо-Западного Федерального округа. Журн неврол и психиатр 2012;112(5):51 —7.</p><p>Парфенов В.А. Профилактика болезни Альцгеймера. Неврол нейропсихиатр психодрических расстройствах непсихотического уровня. Неврол нейропсихиатр психосом 2012;1:67-71.</p><p>Зенцова Н.И., Сирота Н.А. Модель исследования когнитивных факторов психосоциальной адаптации. Вопр наркол 2008;1:61-7.</p><p>Агибалова Т.В., Поплевченков К.Н. Нарушения когнитивных функций у больных опиоидной наркоманией. Журн неврол и психиатр 2012;112(5): 24-8.</p><p>Яхно Н.Н., Захаров В.В., Локшина А.Б. и др. Деменции. 3-е изд. М.: МЕДпресс-информ, 2011;272 с.</p><p>Артемьев Д.В., Захаров В.В., Левин О.В. и др. Старение и нейродегенеративные расстройства: когнитивные и двигательные нарушения в пожилом возрасте. Под ред. Н.Н. Яхно. М.: Servier, 2005;48 с.</p><p>Лурия А.Р. Язык и сознание. М.: Изд-во Моск ун-та, 1979;320 с.</p><p>Wade D.T. Measurement in neurological rehabilitation. Oxford: University Press, 1992;374 p.</p><p>Lovenstone S.S. Gauthier. Management of dementia. London: Martin Dunitz 2001;68 p.</p><p>Dubois B., Stachevsky A., Litvan I. et al. The FAB: a frontal assessement battery at bedside. Neurology 2000;55(5):1621—6.</p><p>Van Holst R.J., Schiet T. Drug-related decrease in neuropsychological functions. Curr Drug Abuse Rev 2011;1:42-56.</p><p>Mitrovic S.M., Vuckovic N., Diskov A. et al. The impact of heroin on visual memory. Eur Rev Med Pharmacol Sci 2011;15(5):524-31.</p><p>Pluck G., Lee K.H., Rele R. Premorbid and current neuropsychological function in opiate abusers receiving treatment. Drug Alcohol Depend 2012;124(1 —2):181—4.</p><p>Чухловина М.Л. Деменция. Диагностика и лечение. СПб.: Питер, 2010;272 с.</p><p>Spiga S., Lintas A., Diana M. Addiction and cognitive functions. Ann NY Acad Sci 2008;1139:299-306.</p><p>Kaschel R. Specific memory effects of ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. Phytomedicine 2011;18(14):1202—7.</p><p>Ihl R., Tribanek M., Bachinskaya N. Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761 in Alzheimers disease and vascular dementia: results from a randomized controlled trial. Pharmacopsychiatry 2012;45(2):41-6.</p><p>Jahanshahi M., Nikmahzar E., Yadollahi N. et al. Protective effects of Ginkgo biloba extract (EGb 761) on astrocytes of rat hippocampus after exposure with scopolamine. Anat cell Biol 2012;45(2):92-6.</p><p>Kehr J., Yoshitake S., Ijiri S. et al. Ginkgo biloba leaf extract (EGb 761) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial pre-frontal cortex. Int Psychogeriatr 2012;24(Suppl1):25-34.</p></div><br />


Review

For citations:


Chukhlovina ML. Cognitive impairments in young people with opioid addiction and their correction. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2012;4(3):45-47. (In Russ.) https://doi.org/10.14412/2074-2711-2012-402

Views: 1152


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)