Current concept of the pathophysiology of migraine and new targets for its therapy
https://doi.org/10.14412/2074-2711-2020-4-143-152
Abstract
Migraine is a common chronic neurological disease. Many neurogenic, vascular, autonomic, and other mechanisms at different levels of the central and peripheral nervous systems are assumed to be implicated in the pathophysiology of headache and other manifestations of migraine. Advances in understanding the neurobiology of migraine have made it possible to clarify the main patterns of neurogenic-vascular relationships that explain the leading clinical manifestations of migraine, as well as to identify some biological markers that have triggered the creation of new targeted therapies for the disease. This review is dedicated to the latest advances in studying the pathophysiology of migraine and to new pharmacological approaches to its treatment.
Keywords
migraine,
pathophysiology,
trigeminovascular system,
calcitonin gene-related peptide (CGRP),
anti-CGRP monoclonal antibodies
Supporting agencies: This article has been supported by Teva. The authors have not received any funding for the preparation of the article.
About the Authors
G. R. Tabeeva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
Guzyal Rafkatovna Tabeeva
Department of Nervous System Diseases and Neurosurgery
11, Rossolimo St., Build. 1, Moscow 119021
Z. Katsapava
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; University of Duisburg-Essen, University Hospital; Evangelical Hospital; EVEX Medical Corporation
Russian Federation
Russian Federation
Department of Nervous System Diseases and Neurosurgery, I.M. Sechenov First Moscow State Medical University
Department of Neurology, University of Duisburg-Essen, University Hospital
Department of Neurology, Evangelical Hospital
11, Rossolimo St., Build. 1, Moscow 119021
Hufelandstr. 55, 45122 Essen, Germany
Holbeinstr 10, 59423 Unna, Germany
40 Vazha-Pshavela Avenue, Tbilisi 0177, Georgia
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Review
For citations:
Tabeeva GR, Katsapava Z. Current concept of the pathophysiology of migraine and new targets for its therapy. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):143-152. https://doi.org/10.14412/2074-2711-2020-4-143-152
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