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Chemoreactic profiling of meloxicam, diclofenac, ibuprofen, ketoprofen, nimesulide, dexketoprofen in transdermal forms

https://doi.org/10.14412/2074-2711-0-0-

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Abstract

The purpose of the study is a comparative modeling of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in transdermal use.

Material and methods. Chemoreactomic profiling of 6 NSAIDs (meloxicam, diclofenac, ibuprofen, ketoprofen, nimesulide, dexketoprofen).

Results and discussion. Compared to other NSAIDs, meloxicam (the active principle of Amelotex gel) accumulates mainly in the muscles and skin and, to a much lesser extent, in the tissues of the heart, lymphocytes, gonads and cartilage. In a model of edema caused by croton oil, meloxicam showed the highest dose-dependent antiedema effect. Analysis of the systemic effects of NSAIDs showed that meloxicam in the least degree affects the metabolism of vitamins A, D, PP, B6 than the other NSAIDs.

Conclusions. The results of a chemoreactomic analysis indicate the possibility of effective and prolonged use of meloxicam in the form of a gel with minimal side effects.

About the Authors

I. Yu. Torshin
FIC IU RAS, Institute of Pharmacoinformatics; Center for Big Data Storage and Analysis, Moscow State University
Russian Federation

Torshin Ivan Yurevich, PhD in Applied Mathematics, leading researcher of the Department of Intellectual  Systems  FRCCSC RAS
Scopus Author ID: 7003300274, SPIN-код: 1375-1114, AuthorID: 54104,  WOS ID C-7683-2018

119333, Moscow, Vavilova, 42



O. A. Gromova
FIC IU RAS, Institute of Pharmacoinformatics; Center for Big Data Storage and Analysis, Moscow State University
Russian Federation

Gromova Olga Alekseevna, Professor, Doctor of Medical Sciences, Science Нead of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems FRCCSC RAS,
SPIN-код: 6317-9833, AuthorID: 94901, Scopus Author ID: 7003589812, WOS ID J-4946-2017

119333, 119333, Moscow, Vavilova, 42



T. R. Grishina
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation
Russian Federation

Grishina Tatiana R., Нead of the Department of pharmacology
AURHOR ID: 113019

153012, 8, Sheremetevskiy avenue, Ivanovo



V. A. Semenov
Kemerovo State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Semenov Vladimir Aleksandrovich, MD, Professor

650056, Kemerovo, ul. Voroshilova, 22A



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For citation:


Torshin I.Yu., Gromova O.A., Grishina T.R., Semenov V.A. Chemoreactic profiling of meloxicam, diclofenac, ibuprofen, ketoprofen, nimesulide, dexketoprofen in transdermal forms. Neurology, Neuropsychiatry, Psychosomatics. 0;. (In Russ.) https://doi.org/10.14412/2074-2711-0-0-

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ISSN 2074-2711 (Print)
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