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Sleep and memory problems: acetylcholine in some neurodegenerative diseases, use of an extended-release formulation of galantamine

https://doi.org/10.14412/2074-2711-2012-394

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Abstract

The paper reviews the literature dedicated to an association between sleep and memory problems and acetylcholine (AC) levels. Moderate impairments of circadian rhythms can develop with aging; however, these changes become quite significant in dementia, which impairs the sleep-wake cycle. Low AC levels during slow-wave sleep are critical for declarative (verbal) memory consolidation. An abnormal nocturnal reduction in cholinergic activity can worsen memory problems and provoke sleep deterioration. The results of the studies suggest that the type of an AC esterase inhibitor and the time of its administration are important for the development of these problems. Galantamine ensures high daytime concentrations of AC and its low nighttime levels, which enables the tone of cholinergic system to be maximally approaches physiological circadian rhythms. This may be essential to the improvement of sleep and memory in patients with dementia.

About the Author

I V Litvinenko

Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Saint Petersburg


References

1. <div><p>Wolkove N. Sleep and aging: 1. Sleep disorders commonly found in older people. CMAJ 2007;176:1299—304.</p><p>Van Someren E.J. Circadian and sleep disturbances in the elderly. Exp Gerontol 2000;35:1229—37.</p><p>Gais S., Born J. Declarative memory consolidation: mechanisms acting during human sleep. Learn Mem 2004;11:679—85.</p><p>Orban P., Rauchs G., Balteau E. et al. Sleep after spatial learning promotes covert reorganization of brain activity. Proc Natl Acad Sci USA 2006;103:7124—9.</p><p>Apostolova L.G., Cummings J.L. Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dem Geriatr Cogn Dis 2008;25(2):115—26.</p><p>Beaulieu-Bonneau S., Hudon C. Sleep disturbances in older adults with mild cognitive impairment.Int Psychogeriatr 2009;21:654—66.</p><p>Montgomery P., Dennis J. Cognitive behavioural interventions for sleep problems in adults aged 60+.Cochrane Database Syst Rev 2003;1:CD003161.</p><p>Arnulf I., Leu S., Oudiette D. Abnormal sleep and sleepiness in Parkinson's disease. Curr Opin Neurol 2008;21(4):472—7.</p><p>Britton T.C., Chaudhuri K.R. REM sleep behavior disorder and the risk of developing Parkinson disease or dementia. Neurology 2009;72(15):1294—5.</p><p>Postuma R.B., Gagnon J.F., Vendette M. et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009;72(15):1296—300.</p><p>Yoritaka A., Ohizumi H., Tanaka S. et al. Parkinson's disease with and without REM sleep behaviour disorder: are there any clinical differences? Eur Neurol 2009;61(3):164—70.</p><p>Day J., Damsma G., Fibiger H.C. Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: an in vivo microdialysis study. Pharmacol Biochem Behav 1991;38:723—9.</p><p>Hasselmo M.E. Neuromodulation: acetylcholine and memory consolidation. Trends Cogn Sci 1999;3:351—9.</p><p>Gais S., Born J. Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation. Proc Natl Acad Sci USA 2004;101:2140—4.</p><p>Гаврилова С.И. Фармакотерапия болезни Альцгеймера. 2-е изд. М.: Пульс, 2007;360 с.</p><p>Дамулин И.В., Яхно Н.Н. Деменции. В кн.: Болезни нервной системы: Рук-во для врачей: в 2 т. Под ред. Н.Н. Яхно. Т. 1. 4-е изд. М.: Медицина, 2005;192—203.</p><p>Захаров В.В., Яхно Н.Н. Когнитивные расстройства в пожилом и старческом возрасте. М., 2005;71 с.</p><p>Rogers S.L., Doody R.S., Mohs R.C. et al. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch Int Med 1998;158:1021—31.</p><p>Seltzer B., Zolnouni P., Nunez M. et al. Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial. Arch Neurol 2004;61:1852—6.</p><p>Kanbayashi T. Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects. Psychiatry Clin Neurosci 2002;56:307—8.</p><p>Mizuno S. Effects of donepezil on Alzheimer's disease: the relationship between cognitive function and rapid eye movement sleep. Psychiatry Clin Neurosci 2004;58:660—5.</p><p>Moraes Wdos S., Poyares D.R., Guilleminault C. et al. The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study. Sleep 2006;29:199—205.</p><p>Singer M., Romero B., Koenig E. et al. Nightmares in patients with Alzheimer's disease caused by donepezil. Therapeutic effect depends on the time of intake. Nervenartz 2005;76(9):1127—9.</p><p>Stahl S.M., Markowitz J.S, Papadopoulos G. et al. Examination of nighttime sleep-related problems during double-blind, placebo-controlled trials of galantamine in patients with Alzheimer's disease. Curr Med Res Opin 2004;20:517—24.</p><p>Jimenez-Capdeville M.E., Dykes R.W. Daily changes in the release of acetylcholine from rat primary somatosensory cortex. Brain Res 1993;625:152—8.</p><p>Литвиненко И.В., Одинак М.М., Могильная В.И. и др. Эффективность и безопасность применения галантамина (реминила) в случаях деменции при болезни Паркинсона. Журн неврол и психиатр 2007;107(12):21—9.</p><p>Левин О.С. Эффективность реминила при деменции с тельцами Леви. Журн невропатол и психиатр 2005;105(10):15—21.</p><p>Литвиненко И.В., Красаков И.В., Тихомирова О.В. Нарушения сна у больных с деменцией при болезни Паркинсона. Журн неврол и психиатр 2011;111(9):37—42.</p><p>Литвиненко И.В. Модуляция холинергической и норадренергической систем уменьшает падения при болезни Паркинсона и синдромах паркинсонизма. Матер. IX Всерос. съезда неврологов. Ярославль, 2006;142.</p><p>Chung K.A., Lobb B.M., Nutt J.G. et al. Cholinergic augmentation reduces falling in Parkinson's disease. 13th International congress of Parkinson's disease and movement disorders, Paris 7—11 June 2009. Poster 193.</p></div><br />


For citation:


Litvinenko I.V. Sleep and memory problems: acetylcholine in some neurodegenerative diseases, use of an extended-release formulation of galantamine. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(2):100-105. (In Russ.) https://doi.org/10.14412/2074-2711-2012-394

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ISSN 2074-2711 (Print)
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