Pharmacogenetics of drug-induced dyskinesias in Parkinson's disease
Abstract
Levodopa remains the gold standard of treating Parkinson's disease (PD). However, the inevitable complication of levodopa therapy is druginduced dyskinesias, which significantly limits the therapeutic capabilities of this group of drugs and requires treatment adjustment. At the same time, patients with PD show not only a wide interindividual variability in the response to levodopa treatment, but also differences in the frequency and time to onset of drug-induced dyskinesias. Therefore, genetic predisposition can play an important role in the development of complications of levodopa therapy.
The paper reviews modern literature on the impact of mutations in the genes, the products of which are involved in the exchange of levodopa and are capable of provoking or, conversely, levelling the development of drug-induced dyskinesias in order to determine the possibilities of expanding the personalized approach to treating patients with PD.
The paper reviews modern literature on the impact of mutations in the genes, the products of which are involved in the exchange of levodopa and are capable of provoking or, conversely, levelling the development of drug-induced dyskinesias in order to determine the possibilities of expanding the personalized approach to treating patients with PD.
About the Authors
A. A. Tappakhov
M.K. Ammosov North-Eastern Federal University, Ministry of Education and Science of Russia;
Yakutsk Research Center for Complex Medical Problems, Ministry of Education and Science of Russia
Russian Federation
Russian Federation
58, Belinsky St., Yakutsk, 677000
4, Sergelyakhskoe Shosse, Yakutsk
T. E. Popova
M.K. Ammosov North-Eastern Federal University, Ministry of Education and Science of Russia;
Yakutsk Research Center for Complex Medical Problems, Ministry of Education and Science of Russia
Russian Federation
Russian Federation
58, Belinsky St., Yakutsk, 677000
4, Sergelyakhskoe Shosse, Yakutsk
T. G. Govorova
M.K. Ammosov North-Eastern Federal University, Ministry of Education and Science of Russia
Russian Federation
Russian Federation
58, Belinsky St., Yakutsk, 677000
N. A. Shnaider
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia
Russian Federation
3, Bekhterev St., Saint Petersburg, 192019
Russian Federation
3, Bekhterev St., Saint Petersburg, 192019
M. R. Sapronova
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk, 660022
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk, 660022
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For citations:
Tappakhov A.A., Popova T.E., Govorova T.G., Shnaider N.A., Sapronova M.R. Pharmacogenetics of drug-induced dyskinesias in Parkinson's disease. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(1):87-92. (In Russ.) https://doi.org/10.14412/2074-2711-2020-1-87-92
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