Drug-induced tardive dyskinesia
Abstract
Tardive dyskinesia (TD) is a type caused by the use of different medications. The pathogenesis of TD is associated with dopamine receptor blockade, gamma-aminobutyric acid depletion, cholinergic deficiency, oxidative stress, impaired synaptic plasticity, and neurotoxicity. TD most often occurs after taking metoclopramide, antipsychotics, antidepressants, calcium channel blockers, and other drugs.
The review considers an adequate assessment of the potential risk of TD when the patient uses prescribed drugs, as well as the monitoring and correction of risk factors for TD, discontinuation or replacement of drugs that potentially cause TD, as well as its treatment.
The review considers an adequate assessment of the potential risk of TD when the patient uses prescribed drugs, as well as the monitoring and correction of risk factors for TD, discontinuation or replacement of drugs that potentially cause TD, as well as its treatment.
About the Authors
T. M. Ostroumova
Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
V. A. Tolmacheva
Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
O. D. Ostroumova
Russian Medical Academy of Continuing Medical Education, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
2/1, Barrikadnaya St., Build. 1, Moscow 125993
16, First Leonov St., Moscow 129226
V. A. Parfenov
Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021
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Review
For citations:
Ostroumova T.M., Tolmacheva V.A., Ostroumova O.D., Parfenov V.A. Drug-induced tardive dyskinesia. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(1):81-86. (In Russ.) https://doi.org/10.14412/2074-2711-2020-1-81-86
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