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Features of comorbidity of menstrual-related migraine

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The key characteristics of migraine are its considerable predominance in reproductive-aged women. Studying the role of gender characteristics in the pathogenesis and clinical manifestations of migraine, as well as the patterns of changes in the level of female sex hormones depending on the menstrual cycle allow menstrual-related migraine to be considered as an independent subtype of the disease with the presence of characteristic clinical symptoms. The role of comorbidity in the development of menstrual-related migraine remains one of the little studied aspects of this problem.
The review presents an update on the patterns of the course of migraine in repriductive-aged women, the effects of hormonal drugs on migraine, and gynecological comorbidity.

About the Authors

E. A. Kiryanova
Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021

G. R. Tabeeva
Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
11, Rossolimo St., Build. 1, Moscow 119021


1. Tabeeva GR, Amelin AV, Akhmadeeva LR, et al. Ways of optimizing the management of patients with migraine in Russia (resolution of the council of experts). Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova. 2018;118(6): 124-8. (In Russ.)

2. Maassen van den Brink A, MacGregor EA, editors. Gender and Migraine. Springer; 2019.

3. Amir BY, Yaacov B, Guy B, et al. Headaches in women undergoing in vitro fertilization and embryo-transfer treatment. Headache. 2005 Mar;45(3):215-9.

4. Serva WA, Serva VM, de Fatima Costa Caminha M, et al. Course of migraine during pregnancy among migraine sufferers before pregnancy. Arq Neuropsiquiatr. 2011 Aug;69(4): 613-9.

5. Vetvik KG, MacGregor EA. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 2017 Jan;16(1):76-87. doi: 10.1016/S1474-4422(16)30293-9. Epub 2016 Nov 9.

6. Sacco S, Merki-Feld GS, Ѓgidius KL, et al. Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). J Headache Pain. 2018 Aug 31; 19(1):76. doi: 10.1186/s10194-018-0896-5.

7. Vos T, Abajobir AA, Abate KH, et al. Regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16; 390(10100):1211-1259. doi: 10.1016/S0140-6736(17)32154-2.

8. Scher AI, Wang SJ, Katsarava Z, et al. Epidemiology of migraine in men: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study. Cephalalgia. 2019 Feb;39(2):296-305. doi: 10.1177/0333102418786266. Epub 2018 Jul 12.

9. Buse DC, Fanning KM, Reed ML, et al. Life With Migraine, Effect on Relationships, Career and Finances, and Overall Health and Well-Being: Results of the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study. Headache. 2019 Sep;59(8):1286-1299. doi: 10.1111/head.13613. Epub 2019 Aug 12.

10. Katsarava Z, Dzagnidze A, Kukava M, et al. Primary headache disorders in the Republic of Georgia: prevalence and risk factors. Neurology. 2009 Nov 24;73(21):1796-803. doi: 10.1212/WNL.0b013e3181c34abb.

11. Buse DC, Manack AN, Fanning KM, et al. Chronic migraine prevalence, disability, and sociodemographic factors: results from the American Migraine Prevalence and Prevention Study. Headache. 2012 Nov-Dec;52(10): 1456-70. doi: 10.1111/j.1526-4610.2012.02223.x. Epub 2012 Jul 25.

12. Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003 Nov;106(1-2):81-9.

13. Maleki N, Kurth T, Field AE. Age at menarche and risk of developing migraine or non-migraine headaches by young adulthood: A prospective cohort study. Cephalalgia. 2017 Nov;37(13):1257-1263. doi: 10.1177/0333102416677999. Epub 2016 Nov 12.

14. Brandes JL. Migraine in women. Continuum (Minneap Minn). 2012 Aug;18(4):835-52. doi: 10.1212/01.CON.0000418646.70149.71.

15. MacGregor EA. Migraine management during menstruation and menopause. Continuum (Minneap Minn). 2015 Aug;21 (4 Headache):990-1003. doi: 10.1212/CON.0000000000000196.

16. Headache Classification Committee of the International Headache Society. HIS The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan; 38(1):1-211. doi: 10.1177/0333102417738202.

17. Pavlovic JM, Stewart WF, Bruce CA, et al. Burden of migraine related to menses: results from the AMPP study. J Headache Pain. 2015 Mar 18;16:24. doi: 10.1186/s10194-015-0503-y.

18. Petrovski BE, Vetvik KG, Lundqvist C, Eberhard-Gran M. Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study. J Headache Pain. 2018 Apr 2;19(1):27. doi: 10.1186/s10194-018-0853-3.

19. Pavlovic JM, Allshouse AA, Santoro NF, et al. Sex hormones in women with and without migraine: Evidence of migraine-specific hormone profiles Neurology. 2016 Jul 5;87(1): 49-56. doi: 10.1212/WNL.0000000000002798. Epub 2016 Jun 1.

20. Li W, Diao X, Chen C, et al. Changes in hormones of the hypothalamic-pituitarygonadal axis in migraine patients. J Clin Neurosci. 2018 Apr;50:165-171. doi: 10.1016/j.jocn.2017.11.011. Epub 2018 Feb 1.

21. Van Oosterhout WPJ, Schoonman GG, van Zwet EW, et al. Female sex hormones in men with migraine Neurology. 2018 Jul 24;91(4): e374-e381. doi: 10.1212/WNL.0000000000005855. Epub 2018 Jun 27.

22. Merki-Feld GS, Imthurn B, Langner R, et al. Positive effects of the progestin desogestrel 75 mug on migraine frequency and use of acute medication are sustained over a treatment period of 180 days. J Headache Pain. 2015;16:522. doi: 10.1186/s10194-015-0522-8. Epub 2015 May 1.

23. Vetvik KG, MacGregor EA, Lundqvist C, Russell MB. Symptoms of premenstrual syndrome in female migraineurs with and without menstrual migraine. J Headache Pain. 2018 Oct 17;19(1):97. doi: 10.1186/s10194-018-0931-6.

24. Ledina AV, Prilepskaya VN, Akimkin VG. Premenstrual Syndrome: Prevalence and the Main Manifestations (the Results of Epidemiological Studies). Epidemiologiya i vaktsinoprofilaktika. 2014;(2):66-71. (In Russ.)

25. Mattsson P. Hormonal factors in migraine: a population-based study of women aged 40 to 74 years. Headache. 2003 Jan;43(1):27-35.

26. Wang SJ, Fuh JL, Lu SR, et al. Migraine prevalence during menopausal transition. Headache. 2003 May;43(5):470-8.

27. Yamada K. High prevalence of menstrual migraine comorbidity in patients with premenstrual dysphoric disorder: retrospective survey. Cephalalgia. 2016 Mar;36(3):294-5. doi: 10.1177/0333102415586066. Epub 2015 May 6.

28. Egilius LH, Spierings AP. Menstrual-Cycle and Menstruation Disorders in Episodic vs Chronic Migraine: An Exploratory Study. Pain Med. 2015 Jul;16(7):1426-32. doi: 10.1111/pme.12788. Epub 2015 Apr 30.

29. Martin VT, Ballard J, Diamond MP, et al. Relief of menstrual symptoms and migraine with a single-tablet formulation of sumatriptan and naproxen sodium. J Womens Health (Larchmt). 2014 May;23(5):389-96. doi: 10.1089/jwh.2013.4577. Epub 2014 Feb 28.

30. Karamustafaoglu B, Kabakci B, Guzey Z, et al. Association between endometriosis, headache, and migraine. Journal of Endometriosis and Pelvic Pain Disorders. 2019;11(1):19-24. doi: 10.1177/2284026518818975

31. Gromova SA, Tabeeva GR. Catamenial migraine: epidemiology, pathogenesis, diagnosis, clinical features. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2): 11-9. (In Russ.). doi: 10.14412/2074-2711-2010-78

32. Teng SW, Horng HC, Ho CH, et al. Women with endometriosis have higher comorbidities: analysis of domestic data in Taiwan. J Chin Med Assoc. 2016 Nov;79(11):577-582. doi: 10.1016/j.jcma.2016.04.006. Epub 2016 Aug 20.

33. Ballweg ML. Impact of endometriosis on women's health: comparative historical data show that the earlier the onset, the more severe the disease. Best Pract Res Clin Obstet Gynaecol. 2004 Apr;18(2):201-18.

34. Chernukha GE, Dumanovskaya MR, Tabeeva GI. Possibilities to apply progesterone receptor selective modulators in women of reproductive age with uterine myoma. Meditsinskii sovet. 2016;(12):126-30. (In Russ.)

35. Karsan N, Goadsby PJ. Biological insights from the premonitory symptoms of migraine. Nat Rev Neurol. 2018 Dec;14(12):699-710. doi: 10.1038/s41582-018-0098-4.

36. Schulte LH, May A. The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain. 2016 Jul;139(Pt 7):1987-93. doi: 10.1093/brain/aww097. Epub 2016 May 5.

37. Sacco S, Ricci S, Degan D, Carolei A. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain. 2012 Apr;13(3):177-89. doi: 10.1007/s10194-012-0424-y. Epub 2012 Feb 26.


For citations:

Kiryanova E.A., Tabeeva G.R. Features of comorbidity of menstrual-related migraine. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(1):76-80. (In Russ.)

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