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Efficacy of paxil in the treatment of depressions in elderly males

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Objective: to study the efficacy of paxil in the treatment of depression of varying severity in elderly male. Patients and methods. Thirty-five males aged 50—78 years with depressive symptoms of varying severity in the framework of a depressive episode [n = 14 (40%)], recurrent depressive disorder [n = 12 (34.3%)], and bipolar affective disorder [n = 9 (25.7%)] were examined. The efficacy of paxil 20—40 mg/day was clinically evaluated using psychometric scales (CGI, HDRS, and UKU) on days 7, 14, 28, and 42. Results. Paxil was found to be highly effective in treating depressions in elderly males. The mean HDRS scores decreased from 24.7±0.3 to 4.9±1.1. By day 42, the reduction in depressive symptoms was 80.2%. 74.3% of the patients achieved recovery and a borderline state according to the CGI-S scale. There was cessation of asthenic symptoms and adynamia at week 1 of therapy, hypothymia at week 2, and anxiety caused by the consecutive manifestations of stimulating, antidepressant, and anxiolytic effects.

About the Authors

N A Tyuvina

Department of Psychiatry and Medical Psychology, I.M. Sechenov First Moscow State Medical University

S V Prokhorova

Department of Psychiatry and Medical Psychology, I.M. Sechenov First Moscow State Medical University

T N Maksimova

Department of Psychiatry and Medical Psychology, I.M. Sechenov First Moscow State Medical University


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For citations:

Tyuvina N.A., Prokhorova S.V., Maksimova T.N. Efficacy of paxil in the treatment of depressions in elderly males. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(2):63-68. (In Russ.)

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