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A change in the parameters of P300 evoked potentials in relation to the degree of exacerbation of pain syndrome

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In chronic pain, the state of suprasegmental brain structures (the cortex, limbic system, truncodiencephalic structures, which form the motivational-affective and cognitive components of pain behavior), actively affects pain afferentation as well. The purpose of the study was to comparatively analyze the parameters and topographic distribution of P300 cognitive evoked potential in patients with lower back pain. Sixty patients aged 22 to 60 years were examined. The authors made their clinical and neurological examinations, collected medical history data, and assessed back pain intensity by a visual analog scale. The findings were compared with the parameters of cognitive evoked potentials (the separating of P300 to count; keystroke in the recognition of significant stimuli; elaboration of a verbal and nonverbal visual stimulation protocol, by using emotionally significant stimuli). The processes of recognition and differentiation, those of directed attention, and the rate of information processing slowed down in patients with different stages of pain syndrome. The P300 separating procedure using the emotionally significant stimuli allows one to assess the specific features of chronization of pain syndromes and the presence of pain memory in the central nervous system of such patients. The estimation of P300 parameters over time or during treatment are of particular value for the optimization and evaluation of its efficiency.


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For citations:

Rachin A.P., Averchenkova A.A. A change in the parameters of P300 evoked potentials in relation to the degree of exacerbation of pain syndrome. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(2):52-55. (In Russ.)

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