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Cervicocranialgia: rationale for and evaluation of the clinical efficiency of therapy with the Russian generics of dexketoprofen and tolperisone

https://doi.org/10.14412/2074-2711-2019-4-94-99

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Abstract

Objective: to comparatively evaluate the clinical efficiency of cervicocranialgia therapy with dexketoprofen (flamadex) and tolperisone (calmyrex), as well as with their combination.
Patients and methods. The investigation enrolled 90 patients aged 30–60 years with cervicocranialgia, who were randomized into three equal groups. Group 1 included 7 men and 23 women who took dexketoprofen; Group 2 consisted of 13 men and 17 women who were prescribed dexketoprofen and tolperisone; Group 3 comprised 18 men and 12 women who used tolperisone. The three patient groups underwent assessment of the intensity of pain on a visual analogue scale and the degree of muscle tone on a 3-point scale and evaluation of the efficiency of therapy and the hemodynamic effect of the drugs in the common carotid and vertebral arteries.
Results and discussion. In all the groups, their treatment reversed neck pain, headache, and dizziness, normalized muscle tone, and improved hemodynamics in the carotid and vertebral arteries. The effect was more pronounced in patients receiving combination treatment (Group 2). The therapy showed a high safety and a good tolerability.
Conclusion. Dexketoprofen and tolperisone have been demonstrated to be effective and safe in treating cervicocranialgia.

About the Authors

M. N. Dadasheva
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Build. 1, Moscow 129110


G. I. Nurullina
Kazan State Medical University, Ministry of Health of Russia
Russian Federation
49, Butlerov St., Kazan 420012


R. V. Gorenkov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
8, Trubetskaya, Build. 2, Moscow 119991


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For citation:


Dadasheva M.N., Nurullina G.I., Gorenkov R.V. Cervicocranialgia: rationale for and evaluation of the clinical efficiency of therapy with the Russian generics of dexketoprofen and tolperisone. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(4):94-99. (In Russ.) https://doi.org/10.14412/2074-2711-2019-4-94-99

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)