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Atherothrombotic stroke in non-valvular atrial fibrillation

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The review analyzes data on the detection rate of and the abilities to predict and prevent non-cardioembolic strokes in non-valvular atrial fibrillation. According to accumulated facts, vitamin K antagonists in non-valvular atrial fibrillation are noted to be inferior to antiplatelet drugs in efficiency in preventing non-cardioembolic (atherothrombotic in particular) strokes, and the widespread use of oral anticoagulants in combination with antiplatelet drugs does not generally reduce the incidence of poor outcomes, markedly increasing the risk of serious bleeding. Nevertheless, it is conceivable that this combination antithrombotic therapy may be useful for certain categories of patients at the highest risk for atherothrombotic stroke and at relatively low risk for hemorrhagic complications. Cohorts of patients, to whom such an approach should be reasonable considered to be applied, have not yet been identified.

About the Authors

I. S. Yavelov
National Medical Research Center of Preventive Medicine, Ministry of Health of Russia
Russian Federation
10, Petroverigsky Lane, Build. 3, Moscow 101990

E. Yu. Okshina
National Medical Research Center of Preventive Medicine, Ministry of Health of Russia
Russian Federation
10, Petroverigsky Lane, Build. 3, Moscow 101990


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For citations:

Yavelov I.S., Okshina E.Yu. Atherothrombotic stroke in non-valvular atrial fibrillation. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(3S):78-81. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)