Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Use of aceclofenac (airtal) in nonspecific back pain and other diseases

Full Text:


The paper gives data on the use of the nonsteroidal anti-inflammatory drug (NSAID) aceclofenac (Airtal) for nonspecific back pain and other diseases. Aceclofenac is noted to be as effective as the most known nonselective NSAIDs (diclofenac, naproxen, indomethacin), at the same time it causes much lower rate of adverse gastrointestinal reactions, including hemorrhage. The authors also provide an analysis of serious side effects of NSAIDs in several countries, which shows that aceclofenac is one of the safest NSAIDs.

About the Authors

V. A. Parfenov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Department of Nervous Diseases

O. N. Gerasimova
Polyclinic Six, ZAO Medical Services
Russian Federation


1. <div><p>Подчуфарова Е.В., Яхно Н.Н. Боль в спине. М., 2010;368 с.</p><p>Эрдес Ш.Ф. и др. Неспецифическая боль в нижней части спины. Клинические рекомендации для участковых терапевтов и врачей общей практики, М., 2008;70 с.</p><p>Van Tulder M., Becker A., Bekkering T. et al. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J 2006;15(Suppl. 2):S169-S191.</p><p>Airaksinen O., Brox J. I., Cedraschi C. et al. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J 2006;15(Suppl. 2):S192-S300.</p><p>Chou R., Qaseem A., Snow V. et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med 2007;147:478-91.</p><p>Chou R., Atlas S.J., Stanos S.P. et al. Nonsurgical interventional therapies for low back pain: a review of the evidence for an American Pain Society clinical practice guideline. Spine (Phila Pa 1976) 2009;34:1078-93.</p><p>Kuijpers T., van Middelkoop M., Rubinstein S.M. et al. A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. Eur Spine J 2011;20:40-50.</p><p>Pareek A., Chandurkar N., Chandanwale A.S. et al. Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J 2009;18:1836-42.</p><p>Diaz C. et al. Efficacy and tolerability of aceclofenac versus diclofenac in the treatment of knee osteoartritis. A multicenter study. Eur J Rheum Suflam 1996;16:17-22.</p><p>Kornasoff D. et al. Aceclofenac is a well - tolerated alternative to naproxen in the treatment of osteoartritis. Clin Rheum 1997;16(1):32-8.</p><p>Pasero G. et al. A multi-center, doubleblind comparative study of the efficacy and safety of aceclofenac and diclofenac. In the treatment of rheumatoid arthritis. Curr Med Res Opin 1995;13:305-15.</p><p>Batlle-Guald E. et al. The efficacy and tolerability of aceclofenac in the treatment of patients with ankylosing spondilatis. A multicenter controlled clinical trial. Aceclofenac Indometacin study Group. J Rheum 1996;23:1200-6.</p><p>Schattenkirchner M., Milachowsk K.A. A double-blind, multi-center clinical trial compuring the efficacy and tolerability of aceclofenac with diclofenac - resinate in patients with acute low back pain. Clin Rheum 2003;22:127-35.</p><p>Lemmel E. M. et al. Patient and Physician Satisfaction with aceclofenac results of the European Observational Cohort study (experiens with aceclofenac for inflammatory pain in daily practice). Curr Med Res Opin 2002;18(3):146-53.</p><p>Huskisson E., Irani M., Murray F. A large prospective open-label, multicentre SAMM study, comparing the safety of aceclofenac with diclofenac in patients with rheumatic disease. Europ J Rheum Inflam 2000;17:1-7.</p><p>Melero L.M.J., Burillo T.J.M., Zaragoza M. Comparative incidence of upper gastrointestinal bleeding associated with individual nonsteroidal anti-inflammatory drugs. Rev Esp Enferm Dig 2002;94:7-18.</p><p>Raber A., Heras J., Costa J. et al. Incidence of spontaneous notifications of adverse reactions with aceclofenac, meloxicam, and rofecoxib during the first year after marketing in the United Kingdom. Ther and Clin Risk Manag 2007;3:225-30.</p><p>Lapeyre-Mestre M., Grolleau S., Montastruc J.L. Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002- 2006. Fund Clin Pharmacol 2011 Sep 20. [Epub ahead of print].</p></div><br />


For citations:

Parfenov V.A., Gerasimova O.N. Use of aceclofenac (airtal) in nonspecific back pain and other diseases. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(4):90-94. (In Russ.)

Views: 2117

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)