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Tobacco smoking dependence in patients with depressive spectrum mental disorders: clinical, pathogenetic, and therapeutic aspects

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This review considers the clinical and pathogenetic aspects of an association between tobacco smoking dependence and depressive spectrum disorders. The comorbidity of these disorders has been established to be to a large extent determined by their common genetic bases. This association substantially affects the efficiency of treatment. Resistance to anti-nicotine and antidepressant medications is associated precisely with the comorbidity of these diseases. To enhance the efficiency of treatment, it is promising to include non-drug methods into the therapeutic complex. This makes it possible to achieve a gradual reduction in tobacco withdrawal syndrome and to prevent an exacerbation of comorbid depression.

About the Authors

O. I. Speranskaya
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministryof Health
Russian Federation

Olga Ivanovna Speranskaya

23, Kropotkinsy Lane, Moscow 119034

S. A. Trushchelev
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministryof Health
Russian Federation

23, Kropotkinsy Lane, Moscow 119034

Z. I. Storozheva
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministryof Health
Russian Federation

23, Kropotkinsy Lane, Moscow 119034


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For citations:

Speranskaya O.I., Trushchelev S.A., Storozheva Z.I. Tobacco smoking dependence in patients with depressive spectrum mental disorders: clinical, pathogenetic, and therapeutic aspects. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):115-120. (In Russ.)

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