Association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs)
Abstract
Objective: to study the association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64-year-old male population from Novosibirsk.
Patients and methods. A representative sample of an open 45–64-year-old male population (n=781) was surveyed within Screening IV of the international HAPIEE program and the WHO MONICA-psychosocial program in 2003–2005. All the study participants filled out the WHO MONICA-psychosocial Program Depression Scale. The DRD2/ANKK1 Taq1A C32806T (rs 1800497) polymorphism was genotyped using the published methods within the budgeting topic. The Pearson's chi-square (2) test was applied to test the statistical significance of differences between the groups. Significance in all types of analysis was taken at p ≤0.05.
Results and discussion. The prevalence of depression in the open 45–64-year-old male population was 36.3%: 13.5% of the examinees had severe depression (SD) and 22.8% had moderate depression (MD). A comparative intergroup analysis showed that the odds ratio (OR) for the incidence of SD was 3.86 times higher in the T/C genotype carriers than in the C/C genotype ones, who, on the contrary, had no depression; the OR for the incidence of SD was also 3.28 times higher in the T/C genotype carriers, while MD was more common in the homozygous C/C genotype carriers. The OR for the incidence of SD was 2.63 times higher in the DRD2 T allele carriers than in the C allele carriers who did not suffer from depression in most cases.
Conclusion. A significant association was established between the carriage of Taq1A (T allele) and depression in 45–64-year-old males.
About the Authors
V. V. GafarovRussian Federation
Valery Vasilyevich Gafarov
Collaborative Laboratory of Cardiovascular Diseases Epidemiology
175/1, B. Bogatkov St., Novosibirsk 630089
E. A. Gromova
Russian Federation
Collaborative Laboratory of Cardiovascular Diseases Epidemiology
175/1, B. Bogatkov St., Novosibirsk 630089
D. O. Panov
Russian Federation
Collaborative Laboratory of Cardiovascular Diseases Epidemiology
175/1, B. Bogatkov St., Novosibirsk 630089
V. N. Maximov
Russian Federation
175/1, B. Bogatkov St., Novosibirsk 630089
I. V. Gagulin
Russian Federation
Collaborative Laboratory of Cardiovascular Diseases Epidemiology
175/1, B. Bogatkov St., Novosibirsk 630089
A. V. Gafarova
Russian Federation
Collaborative Laboratory of Cardiovascular Diseases Epidemiology
175/1, B. Bogatkov St., Novosibirsk 630089
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For citation:
Gafarov V.V., Gromova E.A., Panov D.O., Maximov V.N., Gagulin I.V., Gafarova A.V. Association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs). Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):37-41. https://doi.org/10.14412/2074-2711-2019-2-37-41