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Association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs)

https://doi.org/10.14412/2074-2711-2019-2-37-41

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Abstract

Objective: to study the association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64-year-old male population from Novosibirsk.

Patients and methods. A representative sample of an open 45–64-year-old male population (n=781) was surveyed within Screening IV of the international HAPIEE program and the WHO MONICA-psychosocial program in 2003–2005. All the study participants filled out the WHO MONICA-psychosocial Program Depression Scale. The DRD2/ANKK1 Taq1A C32806T (rs 1800497) polymorphism was genotyped using the published methods within the budgeting topic. The Pearson's chi-square (2) test was applied to test the statistical significance of differences between the groups. Significance in all types of analysis was taken at p ≤0.05.

Results and discussion. The prevalence of depression in the open 45–64-year-old male population was 36.3%: 13.5% of the examinees had severe depression (SD) and 22.8% had moderate depression (MD). A comparative intergroup analysis showed that the odds ratio (OR) for the incidence of SD was 3.86 times higher in the T/C genotype carriers than in the C/C genotype ones, who, on the contrary, had no depression; the OR for the incidence of SD was also 3.28 times higher in the T/C genotype carriers, while MD was more common in the homozygous C/C genotype carriers. The OR for the incidence of SD was 2.63 times higher in the DRD2 T allele carriers than in the C allele carriers who did not suffer from depression in most cases.

Conclusion. A significant association was established between the carriage of Taq1A (T allele) and depression in 45–64-year-old males.

About the Authors

V. V. Gafarov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

Valery Vasilyevich Gafarov

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089



E. A. Gromova
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089



D. O. Panov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089



V. N. Maximov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

175/1, B. Bogatkov St., Novosibirsk 630089



I. V. Gagulin
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089



A. V. Gafarova
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089



References

1. Baron M. Manic-depression genes and the new millennium: poised for discovery. Mol Psychiatry. 2002;7(4):342-58. doi: 10.1038/sj.mp.4000998

2. Morley KI, Hall WD, Carter L. Genetic screening for susceptibility to depression: can we and should we? Aust N Z J Psychiatry. 2004 Jan-Feb;38(1-2):73-80. doi: 10.1111/j.14401614.2004.01300.x

3. Anderson MR, Miller L, Wickramaratne P, et al. Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression. Spiritual Clin Pract (Wash D C). 2017 Mar;4(1):43-63. doi: 10.1037/scp0000125.

4. Eisenstein SA, Bogdan R, Love-Gregory L, et al. Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. Synapse. 2016 Oct;70(10):418-31. doi: 10.1002/syn.21916. Epub 2016 Jun 17.

5. Noble EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2003 Jan 1;116B(1):103-25. doi: 10.1002/ajmg.b.10005

6. Gluskin BS, Mickey BJ. Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies. Transl Psychiatry. 2016 Mar 1;6:e747. doi: 10.1038/tp.2016.22.

7. Nemoda Z, Szekely A, Sasvari-Szekely M. Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neurosci Biobehav Rev. 2011 Aug; 35(8):1665-86. doi: 10.1016/j.neubiorev.2011.04.002. Epub 2011 Apr 15.

8. Savitz J, Hodgkinson CA, Martin-Soelch C, et al. DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. Int J Neuropsychopharmacol. 2013 Oct;16(9): 2095-101. doi: 10.1017/S146114571300045X. Epub 2013 May 20.

9. Stapleton JA, Sutherland G, O'Gara C, et al. Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. Pharmacogenet Genomics. 2011 Aug;21(8): 447-53. doi: 10.1097/FPC.0b013e328347473a.

10. Elovainio M, Jokela M, KivimКki M, et al. Genetic Variants in the DRD2 Gene Moderate the Relationship Between Stressful Life Events and Depressive Symptoms in Adults: Cardiovascular Risk in Young Finns Study. Psychosom Med. 2007 Jun;69(5):391-5. doi: 10.1097/psy.0b013e31806bf365

11. UCL department of epidemiology and public health central and eastern europe research group HAPIEE Study. http://www.ucl.ac.uk/easteurope/hapiee-cohort.htm

12. MONICA Monograph and Multimedia Sourcebook. Helsinki; 2003. 237 p.

13. Hirvonen M, Laakso A, Nagren K, et al. C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Mol Psychiatry. 2004 Dec; 9(12):1060-1. doi: 10.1038/sj.mp.4001561

14. Byuyul' A, Tsefel' P. SPSS: iskusstvo obrabotki informatsii. Analiz statisticheskikh dannykh i vosstanovlenie skrytykh zakonomernostei [SPSS: the art of information processing. The analysis of statistical data and hidden patterns restore]. Saint-Petersburg: DiaSoftYuP; 2015. 608 p.

15. Pandis N. The chi-square test. Am J Orthod Dentofacial Orthop. 2016 Nov;150(5):898-899. doi: 10.1016/j.ajodo.2016.08.009.

16. Blum K, Kozlowski GP. Ethanol and neuromodulator interactions: a cascade model of reward. In: Ollat H, Parvez S, Parvez H, editors. Alcohol and Behavior. Utrecht: VSP Press; 1990. P. 131-49.

17. Whitmer AJ, Gotlib IH. Depressive rumination and the C957T polymorphism of the DRD2 gene. Cogn Affect Behav Neurosci. 2012 Dec;12(4):741-7. doi: 10.3758/s13415-0120112-z.

18. Roetker NS, Yonker JA, Lee C, et al. Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study. BMJ Open. 2012 Jul 2;2(4). pii: e000944. doi: 10.1136/bmjopen-2012-000944. Print 2012.

19. Zhang W, Cao Y, Wang M, et al. The dopamine D2 receptor polymorphism (DRD2 Taq1A) interacts with maternal parenting in predicting early adolescent depressive symptoms: evidence of differential susceptibility and age differences. J Youth Adolesc. 2015 Jul;44(7): 1428-40. doi: 10.1007/s10964-015-0297-x. Epub 2015 May 5.

20. Zhang L, Hu L, Xin L, et al. The DRD2 rs1800497 polymorphism increase the risk of mood disorder: Evidence from an updated meta-analysis. J Affect Disord. 2014 Apr;158: 71-7. doi: 10.1016/j.jad.2014.01.015. Epub 2014 Feb 10.


For citation:


Gafarov V.V., Gromova E.A., Panov D.O., Maximov V.N., Gagulin I.V., Gafarova A.V. Association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs). Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):37-41. (In Russ.) https://doi.org/10.14412/2074-2711-2019-2-37-41

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)