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Orthostatic hypotension as a modifiable risk factor for cognitive impairment: a literature review

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Age-related diseases are becoming an important public health problem due to the rise in the number of elderly and senile people around the world. In this age group, the prevalence of cognitive impairment (CI) no dementia and dementia is great, which determines a significant deterioration in quality of life. Orthostatic hypotension (OH) that is also often detectable at elderly and senile ages is one of the possible risk factors for CI and dementia. The paper reviews publications a relationship between OH and risk for CI/dementia in patients from older age group. Although the results of studies are contradictory, a number of studies and meta-analysis indicate a relationship between OH and CI/dementia in elderly and senile patients. Timely diagnosis of OH will be able not only to identify groups at risk for CI and/or dementia, but also to implement preventive measures in time to reduce this risk.

About the Authors

O. D. Ostroumova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Olga Dmitrievna Ostroumova

Department of Clinical Pharmacology and Internal Diseases Propedeutics, Faculty of General Medicine.

SD «Russian Gerontological Scientific-Clinical Center»

8, Trubetskaya St., Build. 2, Moscow,  

119991; 216, 1st Leonova St., Moscow 129226


E. V. Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Clinical Pharmacology and Internal Diseases Propedeutics, Faculty of General Medicine

8, Trubetskaya St., Build. 2, Moscow 

E. V. Rebrova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Clinical Pharmacology and Internal Diseases Propedeutics, Faculty of General Medicine

8, Trubetskaya St., Build. 2, Moscow 

A. Yu. Ryazanova
Volgograd State Medical University, Ministry of Health of Russia
Russian Federation

Department of Clinical Pharmacology and Intensive Therapy with Course of Clinical Pharmacology, Faculty for Postgraduate Training of Physicians, and Department of Clinical Allergology, Faculty for Postgraduate Training of Physicians

1, Pavshikh Bortsov Sq.,Volgograd 400131


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For citations:

Ostroumova O.D., Shikh E.V., Rebrova E.V., Ryazanova A.Yu. Orthostatic hypotension as a modifiable risk factor for cognitive impairment: a literature review. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):109-116. (In Russ.)

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