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Cognitive impairment in primary hyperparathyroidism

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Cognitive impairment (CI) is a nonclassical manifestation of primary hyperparathyroidism associated with impaired calcium and phosphorus metabolism. The pathophysiological mechanisms of cognitive dysfunction in this endocrine disease have not been fully elucidated. Nonetheless, studies have demonstrated neuropsychological improvements and better quality of life in patients who have achieved normocalcemia with reduced parathyroid hormone levels after surgical treatment for hyperparathyroidism. Further large-scale controlled studies are needed to determine the possibility of using neuropsychiatric complications as indications for parathyroidectomy.

About the Authors

N. G. Mokrysheva
National Medical Research Center for Endocrinology, Ministry of Health of Russia
Russian Federation

11, Dm. Ulyanov St., Moscow 117036

Yu. A. Krupinova
National Medical Research Center for Endocrinology, Ministry of Health of Russia
Russian Federation

11, Dm. Ulyanov St., Moscow 117036

E. E. Bibik
National Medical Research Center for Endocrinology, Ministry of Health of Russia
Russian Federation

Ekaterina Evgenyevna Bibik

11, Dm. Ulyanov St., Moscow 117036

G. A. Melnichenko
National Medical Research Center for Endocrinology, Ministry of Health of Russia
Russian Federation

11, Dm. Ulyanov St., Moscow 117036


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For citations:

Mokrysheva N.G., Krupinova Yu.A., Bibik E.E., Melnichenko G.A. Cognitive impairment in primary hyperparathyroidism. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):103-108. (In Russ.)

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