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The modern concept of cognitive reserve

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The main forms of cognitive impairment (CI) are characterized by a significant variability in the relationship between morphological changes and clinical manifestations. One of the promising concepts, which explains these features, is a modern model of cognitive reserve. The cognitive reserve concept that is most widely used in the context of dementia is often employed to explain the mechanisms, by which the functional systems of the brain resist neuropathological changes. The mechanisms that ensure cognitive reserve function in the health and disease of the brain are to activate its neuronal connections. Therefore, individuals with more efficient neuronal connections and an ability to form alternative neural networks and, accordingly, to create cognitive strategies in response to increased cognitive load are characterized by greater cognitive reserve. The modern concept of cognitive reserve opens up prospects for explaining the causes and mechanisms of development of CI and also justifies the possibilities of using alternative strategies for their correction.

About the Authors

N. N. Koberskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Nadezhda Nikolaevna Koberskaya

Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine

11, Rossolimo St., Build. 1, Moscow 119021

G. R. Tabeeva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine

11, Rossolimo St., Build. 1, Moscow 119021


1. Marois R, Ivanoff J. Capacity limits of information processing in the brain. Trends Cogn Sci. 2005 Jun;9(6):296-305.

2. Kopell NJ, Gritton HJ, Whittington MA, Kramer MA. Beyond the connectome: the dynome. Neuron. 2014 Sep 17;83(6):1319-28. doi: 10.1016/j.neuron.2014.08.016.

3. Medaglia JD, Lynall ME, Bassett DS. Cognitive network neuroscience. J Cogn Neurosci. 2015 Aug;27(8):1471-91. doi: 10.1162/jocn_a_00810. Epub 2015 Mar 24.

4. Da Silva FL, Blanes W, Kalitzin SN, et al. Epilepsies as dynamic diseases of brain systems: basic models of the transition between normal and epileptic activity. Epilepsia. 2003;44 Suppl 12:72-83.

5. Pezard L, Nandrino JL, Renault B, et al. Depression as a dynamic disease. Biol Psychiatry. 1996 Jun 15;39(12):991-9.

6. Van den Heuvel MP, Sporns O. Network hubs in the human brain. Trends Cogn Sci. 2013 Dec; 17(12):683-96. doi: 10.1016/j.tics.2013.09.012.

7. Stam CJ. Modern network science of neurological disorders. Nat Rev Neurosci. 2014 Oct; 15(10):683-95. doi: 10.1038/nrn3801. Epub 2014 Sep 4.

8. Katzman R, Aronson M, Fuld P, et al. Development of dementing illnesses in an 80-year-old volunteer cohort. Ann Neurol. 1989 Apr;25(4):317-24.

9. Stern Y. What is cognitive reserve? Theory and research Application of the reserve concept. J Int Neuropsychol Soc. 2002 Mar;8(3):448-60.

10. Graves AB, Mortimer JA, Larson EB, et al. Head circumference as a measure of cognitive reserve. Association with severity of impairment in Alzheimer's disease. Br J Psychiatry. 1996 Jul; 169(1):86-92.

11. Murray AD, Staff RT, McNeil CJ, et al. The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases. Brain. 2011 Dec; 134(Pt 12):3687-96. doi: 10.1093/brain/awr259. Epub 2011 Nov 18.

12. Perneczky R, Green RC, Kurz A. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology. 2010 Jul 13;75(2):137-42. doi: 10.1212/WNL.0b013e3181e7ca97.

13. Satz P. Brain reserve capacity on symptom onset after brain injury: A formulation and review of evidence for threshold theory. Neuropsychology. 1993;7(3):273.

14. Schofield PW, Logroscino G, Andrews HF, et al. An association between head circumference and Alzheimer's disease in a populationbased study of aging and dementia. Neurology. 1997 Jul;49(1):30-7.

15. Stern Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord. 2006 AprJun;20(2):112-7.

16. Grady CL, Horwitz B, Pietrini P, et al. The effect of task difficulty on cerebral blood flow during perceptual matching of faces. Hum Brain Mapp. 1996;4(4):227-39. doi: 10.1002/(SICI)1097-0193(1996)4:4<227::AID-HBM1>3.0.CO;2-5..

17. Grasby PM, Frith CD, Friston KJ, et al. A graded task approach to functional mapping of areas implicated in auditory-verbal memory. Brain. 1994 Dec;117 ( Pt 6):1271-82.

18. Gur RC, Gur RE, Skolnick BE, et al. Effects of task difficulty on regional cerebral blood flow: Relationships with anxiety and performance. Psychophysiology. 1988 Jul;25(4): 392-9.

19. Becker JT, Mintun MA, Aleva K, et al. Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease. Neurology. 1996 Mar; 46(3):692-700.

20. Deutsch G, Halsey JH, Harrell LE. Exaggerated cortical blood flow reactivity in early Alzheimer's disease during successful task performance. J Clin Exp Neuropsychol. 1993 Jan;15(1):71.

21. Grady CL, Haxby JV, Horwitz B, et al. Activation of cerebral blood flow during a visuoperceptual task in patients with Alzheimer type dementia. Neurobiol Aging. 1993 Jan-Feb; 14(1):35-44.

22. Herbster AN, Nichols T, Wiseman MB, et al. Functional connectivity in auditory-verbal short-term memory in Alzheimer's disease. Neuroimage. 1996 Oct;4(2):67-77.

23. Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012 Nov; 11(11):1006-12. doi: 10.1016/S1474-4422(12)70191-6.

24. Snowdon DA, Kemper SJ, Mortimer JA, et al. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA. 1996 Feb 21;275(7):528-32.

25. Prohovnik I, Mayeux R, Sackeim HA, et al. Cerebral perfusion as a diagnostic marker of early Alzheimer's disease. Neurology. 1988 Jun; 38(6):931-7.

26. Foster NL, Chase TN, Mansi L, et al. Cortical abnormalities in Alzheimer's disease. Ann Neurol. 1984 Dec;16(6):649-54.

27. Brun A, Englund E. Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading. Histopathology. 1981 Sep;5(5):549-64.

28. Pearson RC, Esiri MM, Hiorns RW, et al. Anatomical correlates of the distribution of pathological changes in the neocortex in Alzheimer's disease. Proc Natl Acad Sci U S A. 1985 Jul;82(13):4531-4.

29. Rogers J, Morrison JH. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci. 1985 Oct;5(10):2801-8.

30. Stern Y, Alexander GE, Prohovnik I, Mayeux R. Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann Neurol. 1992 Sep;32(3): 371-5.

31. Alexander GE, Furey ML, Grady CL, et al. Association of premorbid function with cerebral metabolism in Alzheimer's disease: Implications for the reserve hypothesis. Am J Psychiatry. 1997 Feb;154(2):165-72.

32. Bonaiuto S, Rocca WA, Lippi A, et al. Impact of education and occupation on prevalence of Alzheimer's disease (AD) and multiinfarct dementia (MID) in Appignano, Macerata Province, Italy. Neurology. 1990; 40(Suppl. 1):346.

33. Callahan CM, Hall KS, Hui SL, et al. Relationship of age, education, and occupation with dementia among a community-based sample of African Americans. Arch Neurol. 1996 Feb;53(2):134-40.

34. Glatt SL, Hubble JP, Lyons K, et al. Risk factors for dementia in Parkinson's disease: Effect of education. Neuroepidemiology. 1996 Jan-Feb;15(1):20-5.

35. Gurland BJ, Wilder D, Cross P, et al. Relative rates of dementia by multiple case definitions, over two prevalence periods, in three cultural groups. Am J Geriatr Psychiatry. 1995 Winter;3(1):6-20. doi: 10.1097/00019442-199524310-00002. Epub 2012 Aug 8.

36. Hill LR, Klauber MR, Salmon DP, et al. Functional status, education, and the diagnosis of dementia in the Shanghai survey. Neurology. 1993 Jan;43(1):138-45.

37. Korczyn AD, Kahana E, Galper Y. Epidemiology of dementia in Ashkelon, Israel. Neuroepidemiology. 1991;10:100.

38. Mortel KF, Meyer JS, Herod B, Thornby J. Education and occupation as risk factors for dementia of the Alzheimer and ischemic vascular types. Dementia. 1995 Jan-Feb;6(1):55-62.

39. Evans DA, Beckett LA, Albert MS, et al. Level of education and change in cognitive function in a community population of older persons. Ann Epidemiol. 1993 Jan;3(1):71-7.

40. Letenneur L, Commenges D, Dartigues JF, Barberger-Gateau P. Incidence of dementia and Alzheimer's disease in elderly community residents of south-western France. Int J Epidemiol. 1994 Dec;23(6):1256-61.

41. Stern Y, Gurland B, Tatemichi TK, et al. (1994). Influence of education and occupation on the incidence of Alzheimer's disease. JAMA. 1994 Apr 6;271(13):1004-10.

42. White L, Katzman R, Losonczy K, et al. Association of education with incidence of cognitive impairment in three established populations for epidemiological studies of the elderly. J Clin Epidemiol. 1994 Apr;47(4):363-74.

43. Stern Y, Albert S, Tang MX, Tsai WY. (1999). Rate of memory decline in AD is related to education and occupation: Cognitive reserve? Neurology. 1999 Dec 10;53(9):1942-7.

44. Teri L, McCurry SM, Edland SD, et al. Cognitive decline in Alzheimer's disease: A longitudinal investigation of risk factors for accelerated decline. J Gerontol A Biol Sci Med Sci. 1995 Jan;50A(1):M49-55.

45. Albert MS, Jones K, Savage CR, et al. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging. 1995 Dec;10(4):578-89.

46. Butler SM, Ashford JW, Snowdon DA. Age, education, and changes in the Mini-Mental State Exam scores of older women: Findings from the Nun Study. J Am Geriatr Soc. 1996 Jun;44(6):675-81.

47. Farmer ME, Kittner SJ, Rae DS, et al. Education and change in cognitive function: The epidemiologic catchment area study. Ann Epidemiol. 1995 Jan;5(1):1-7.

48. Snowdon DA, Ostwald SK, Kane RL. Education, survival and independence in elderly Catholic sisters, 1936-1988. Am J Epidemiol. 1989 Nov;130(5):999-1012.

49. Geerlings MI, Schmand B, Braam AW, et al. Depressive symptoms and risk of Alzheimer's disease in more highly educated older people. J Am Geriatr Soc. 2000 Sep;48(9): 1092-7.

50. Aksari P, Stoppe G. Risk factors in Alzheimer's dementia. Fortschr Neurol Psychiatr. 1996 Nov;64(11):425-32.

51. Mori E, Hirono N, Yamashita H, et al. Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease. Am J Psychiatry. 1997 Jan; 154(1):18-24.

52. Cobb JL, Wolf PA, Au R, et al. The effect of education on the incidence of dementia and Alzheimer's disease in the Framingham Study. Neurology. 1995 Sep;45(9):1707-12.

53. Del Ser T, Gonzalez-Montalvo JI, Martinez-Espinosa S, et al. Estimation of premorbid intelligence in Spanish people with the Word Accentuation Test and its application to the diagnosis of dementia. Brain Cogn. 1997 Apr; 33(3):343-56.

54. Fratiglioni L, Grut M, Forsell Y, et al. Prevalence of Alzheimer's disease and other dementias in an elderly urban population: Relationship with age, sex and education. Neurology. 1991 Dec;41(12):1886-92.

55. Albert SM, Teresi JA. Reading ability, education, and cognitive status assessment among older adults in Harlem, New York City. Am J Public Health. 1999 Jan;89(1):95-7.

56. Katzman R. (1993). Epidemiology, education, and the ecology of Alzheimer's disease. Neurology. 1993 Jan;43(1):13-20.

57. Swaab DF, Lucassen PJ, Salehi A, et al. Reduced neuronal activity and reactivation in Alzheimer's disease. Prog Brain Res. 1998;117: 343-77.

58. Gould E, Reeves AJ, Graziano MS, Gross CG. Neurogenesis in the neocortex of adult primates. Science. 1999 Oct 15;286(5439):548-52.

59. Fratiglioni L, Wang H. Brain reserve hypothesis in dementia. J Alzheimers Dis. 2007 Aug;12(1):11-22.

60. Sattler C, Toro P, Schö nknecht P, Schrö der J. Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer's disease. Psychiatry Res. 2012 Mar 30;196(1):90-5. doi: 10.1016/j.psychres.2011.11.012. Epub 2012 Mar 4.

For citation:

Koberskaya N.N., Tabeeva G.R. The modern concept of cognitive reserve. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):96-102. (In Russ.)

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