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Anti-MOG syndrome: two case reports

https://doi.org/10.14412/2074-2711-2019-1-84-88

Abstract

The paper describes two cases of adolescent-onset anti-MOG (myelin oligodendrocyte glycoprotein) syndrome. One case had an onset of optic neuritis, followed by myelitis; a recurrence of the syndrome occurred during interferon-β therapy. In the other case the syndrome also began with optic neuritis; and after a long latent period it was manifested as unilateral encephalitis with contralateral hemiparesis and rare epileptic seizures. Detection of anti-MOG syndrome is of great importance, because its management tactics is different from that for multiple sclerosis; furthermore, the laboratory diagnosis of this syndrome can be made in our country now.

About the Author

A. S. Kotov
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

Aleksey Sergeevich Kotov

61/2, Shchepkin St., Moscow 129110



References

1. Kira J. Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis. Pathophysiology. 2011 Feb;18(1):69-79. doi: 10.1016/j.pathophys.2010.04.008. Epub 2010 May 21.

2. Lana-Peixoto MA, Callegaro D. The expanded spectrum of neuromyelitis optica: evidences for a new definition. Arq Neuropsiquiatr. 2012 Oct;70(10):807-13.

3. Dos Passos GR, Oliveira LM, da Costa BK, et al. MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder. Front Neurol. 2018 Apr 4;9:217. doi: 10.3389/fneur.2018.00217. eCollection 2018.

4. Mariotto S, Ferrari S, Monaco S, et al. Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study. J Neurol. 2017 Dec;264(12):2420-2430. doi: 10.1007/s00415-017-8635-4. Epub 2017 Oct 23.

5. Kotov AS, Andryukhina OM, Matyuk YuV, et al. Optic neuritis and myelitis in teenager: Devick’s opticomyelitis or multiple sclerosis? Nevrologicheskii zhurnal. 2015;20(6): 35-40. (In Russ.).

6. Fukushima N, Suzuki M, Ogawa R, et al. A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis cooccurring with unilateral cerebral cortical encephalitis. Rinsho Shinkeigaku. 2017 Nov 25; 57(11):723-728. doi: 10.5692/clinicalneurol.cn-001078. Epub 2017 Oct 26.

7. Ramanathan S, O'grady GL, Malone S, et al. Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children. Dev Med Child Neurol. 2018 Sep 17. doi: 10.1111/dmcn.14032. [Epub ahead of print]

8. Stellmann JP, Krumbholz M, Friede T, et al; NEMOS (Neuromyelitis Optica Study Group). Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response. J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):639-647. doi: 10.1136/jnnp-2017-315603. Epub 2017 Jun 1.

9. Kira JI. Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others? Mult Scler. 2017 Aug;23(9):1300-1302. doi: 10.1177/1352458517703803. Epub 2017 Apr 10.

10. Isaikin AI, Shmidt TE, Yakhno NN, et al. Neuromyelitis optica. Nevrologicheskii zhurnal. 2014;19(5):43-51. (In Russ.).

11. Belova AN, Boiko AN, Belova EM. Diagnostic criteria for neuromyelitis optica spectrum disorders. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(2-2):32-40. (In Russ.).

12. Ramanathan S, Dale RC, Brilot F. AntiMOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun Rev. 2016 Apr;15(4):307-24. doi: 10.1016/j.autrev.2015.12.004. Epub 2015 Dec 17.

13. Papp V, Langkilde AR, Blinkenberg M, et al. Clinical utility of anti-MOG antibody testing in a Danish cohort. Mult Scler Relat Disord. 2018 Nov;26:61-67. doi: 10.1016/j.msard.2018.09.010. Epub 2018 Sep 11


Review

For citations:


Kotov AS. Anti-MOG syndrome: two case reports. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):84-88. https://doi.org/10.14412/2074-2711-2019-1-84-88

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)