Approaches to therapy for depressions in neurology: prospects for the use of agomelatine
https://doi.org/10.14412/2074-2711-2018-4-101-110
Abstract
This review provides information on prospects for using the antidepressant agomelatine in neurological practice. The drug has a unique receptor profile, being a melatonin receptor type 1 and 2 agonist and a serotonin receptor subtype 2C antagonist. Due to this and in addition to antidepressant action, the drug has a number of other effects, such as analgesic, anti-apathetic, anti-asthenic, procognitive, anxiolytic, and sleep-normalizing ones, which are of great importance in the treatment of neurological diseases. There are clinical and experimental data that prove the high efficiency and safety of agomelatin in the follow-up of patients with post-stroke depression, Parkinson’s disease, Alzheimer’s disease, Pick’s disease, Huntington’s disease, chronic fatigue syndrome, and pain syndromes.
Keywords
agomelatine (valdoxan),
depression,
anxiety,
pain,
cognitive impairment,
insomnia,
asthenia,
apathy,
neurology
About the Authors
D. V. Romanov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research Center
Russian Federation
Russian Federation
Department of Psychiatry and Psychosomatics, Faculty of General Medicine.
8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552
B. A. Volel
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research Center
Russian Federation
Russian Federation
Beatrice Albertovna Volel - Department of Psychiatry and Psychosomatics, Faculty of General Medicine.
8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552
D. S. Petelin
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research Center
Russian Federation
Russian Federation
Department of Psychiatry and Psychosomatics, Faculty of General Medicine.
8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552
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For citations:
Romanov D.V., Volel B.A., Petelin D.S. Approaches to therapy for depressions in neurology: prospects for the use of agomelatine. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(4):101-110. (In Russ.) https://doi.org/10.14412/2074-2711-2018-4-101-110
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