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The brain’sglymphatic system:physiological anatomy and clinical perspectives

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The recently discovered glymphatic system (GS) ensures the efficient clearance of interstitial fluid and soluble compounds from the central nervous system into cerebrospinal fluid (CSF), which compensates for the lack of conventional lymphatic vessels in the brain parenchyma. This unique anatomical and physiological phenomenon had been unknown until 2012. GS lacks inherent proper vessels Р the current of CSF and interstitial fluid is carried out directly inside the arterial walls (the perivascular pathway) or near the walls of the cerebral arteries and veins (the paravascular pathway). Current biorheological technologies could establish a special role of aquaporin-4 in the filtration of CSF and interstitial fluid. The close link between GS and the CSF circulatory system allows the established views on fluid dynamics within the brain to be reconsidered. The discovery of GS can contribute to our understanding of the pathogenesis of increased intracranial pressure and neurodegenerative diseases, as well as to the elaboration of new therapeutic approaches to their treatment.

About the Authors

V. N. Nikolenko
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Human Anatomy and; Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991; 11, Rossolimo St., Build. 1, Moscow 119021

M. V. Oganesyan
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Human Anatomy and.

8, Trubetskaya St., Build. 2, Moscow 119991

N. N. Yakhno
M.V. Lomonosov Moscow State University
Russian Federation

Department of Normal and Topographic Anatomy.

1, Leninskie Gory, Moscow 119234

E. A. Orlov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Human Anatomy and; Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991

E. E. Porubayeva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Human Anatomy and.

8, Trubetskaya St., Build. 2, Moscow 119991

E. Yu. Popova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Ekaterina Yuryevna Popova - Department of Human Anatomy and; Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991


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For citation:

Nikolenko V.N., Oganesyan M.V., Yakhno N.N., Orlov E.A., Porubayeva E.E., Popova E.Yu. The brain’sglymphatic system:physiological anatomy and clinical perspectives. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(4):94-100. (In Russ.)

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