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New drugs for anti-B-cell therapy of multiple sclerosis

https://doi.org/10.14412/2074-2711-2018-1-70-73

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Abstract

The review presents the data characterizing the mechanism of action of anti-B-cell therapy for multiple sclerosis (MS) and the results of clinical trials of ocrelizumab, the first drug of this group, which has been approved for use in MS. Multicenter randomized controlled studies have shown that this drug is effective in treating both MS with exacerbations and primary progressive MS. Currently ocrelizumab is the only drug that can be used as a pathogenetic treatment for this MS course type.

About the Authors

A. N. Boyko
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology, Neurosurgery, and Medical Genetics, 

1, Ostrovityanov St., Moscow 117997



N. Yu. Lashch
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology, Neurosurgery, and Medical Genetics, 

1, Ostrovityanov St., Moscow 117997



M. E. Guseva
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology, Neurosurgery, and Medical Genetics, 

1, Ostrovityanov St., Moscow 117997



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For citation:


Boyko A.N., Lashch N.Y., Guseva M.E. New drugs for anti-B-cell therapy of multiple sclerosis. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):70-73. (In Russ.) https://doi.org/10.14412/2074-2711-2018-1-70-73

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)