Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment
https://doi.org/10.14412/2074-2711-2018-1-12-16
Abstract
Vascular myelopathy is a rare severe disease caused by a broad spectrum of causes, among which pathology of the aorta and its branches, aortic surgery, spinal diseases, and spinal trauma occupy the main place. The processes of neuroinflammation and glutamate neurotoxicity play a leading role in the pathogenesis of myeloischemia. The clinical picture of the disease is nonspecific and depends on the location and volume of an ischemic focus. Magnetic resonance imaging is a gold standard for diagnosis. However, this method remains insensitive in the acute period and fails to detect spinal cord ischemia at preclinical stages. The investigation and introduction of specific biochemical markers (glutamate receptors and their antibodies) for neurotoxicity, which can identify ischemia in the advanced stage and predetermine its development, are promising. The treatment of vascular myelopathy has not currently been standardized and it is mainly pathogenetic and symptomatic.
Keywords
spinal cord,
ischemia,
causes,
mechanisms,
clinical picture,
diagnosis,
treatment,
biomarkers,
glutamate
About the Authors
G. V. Ponomarev
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
A. A. Skoromets
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
V. S. Krasnov
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
O. V. Rodionova
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
D. D. Glistenkova
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
N. F. Porkhun
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
S. A. Dambinova
Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology,
6–8, Lev Tolstoy St., Saint Petersburg 197022
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Review
For citations:
Ponomarev G.V., Skoromets A.A., Krasnov V.S., Rodionova O.V., Glistenkova D.D., Porkhun N.F., Dambinova S.A. Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):12-16. (In Russ.) https://doi.org/10.14412/2074-2711-2018-1-12-16
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