Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Sleep disorders in Parkinson’s disease: approaches to treatment and prevention

https://doi.org/10.14412/2074-2711-2017-4-88-84

Full Text:

Abstract

Nocturnal sleep disorders are one of the most important non-motor manifestations of Parkinson’s disease (PD). The clinical significance of sleep disorders in PD is determined by their frequency (up to 88%) and negative impact on quality of life in patients. The paper presents the clinical spectrum of sleep disorders in PD, current approaches to their diagnosis. It discusses the multifactorial nature of the pathophysiology of these disorders. Current views on the relationship of sleep disorders to the neurodegeneration of brain structures involved in the regulation of sleep and wakefulness, to circadian disorders and therapy are depicted. On the basis of the heterogeneity of sleep disorders in PD, a differentiated approach to their treatment is substantiated having regard to the nature of dyssomnic disorders and leading pathophysiological factors. Emphasis is focused on the basic principles of differentiated therapy for sleep disorders in PD in relation to the degree of nocturnal motor symptoms of the disease. There are clinical findings indicating an improvement in the characteristics of nocturnal sleep and a reduction in nocturnal sleep disorders during therapy with long- acting ropinirole, a D2-receptor agonist. Approaches to the pharmacotherapy of non-motor disorders of PD, which worsen nocturnal sleep, are depicted. Non-drug therapies for sleep disorders and their efficiency in patients with PD are discussed.

About the Authors

M. R. Nodel
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases and Neurosurgery

Research Department of Neurology, Science and Technology Park of Biomedicine

11, Rossolimo St., Moscow 119021



G. V. Kovrov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Research Department of Neurology, Science and Technology Park of Biomedicine

11, Rossolimo St., Moscow 119021



References

1. Factor SA, McAlarney T, Sanchez-Ramos JR., Wiener WJ. Sleep disorders and sleep effect in Parkinson’s disease. Mov Disord. 1990;5(4): 280-5.

2. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson's disease. Mov Disord. 1998 Nov;13(6):895-9.

3. Нодель МР, Яхно НН, Украинцева ЮВ, Дорохов ВБ. Инсомния при болезни Паркинсона и ее влияние на качество жизни пациентов. Неврологический журнал. 2014;(4):19-27. [Nodel' MR, Yakhno NN, Ukraintseva YuV, Dorokhov VB. Insomnia in Parkinson's disease and its impact on the quality of life of patients. Nevrologicheskii zhurnal. 2014;(4):19-27. (In Russ.)].

4. Arnulf I. REM sleep behavior disorder: motor manifestations and pathophysiology. Mov Disord. 2012 May;27(6):677-89. doi: 10.1002/mds.24957. Epub 2012 Mar 22.

5. Нодель МР, Украинцева ЮВ, Яхно НН. Синдром нарушения поведения в фазе сна с быстрыми движениями глаз при болезни Паркинсона. Неврологический журнал. 2015; (6);28-34. [Nodel' MR, Ukraintseva YuV, Yakhno NN. Syndrome of behavioral disturbances in the sleep phase with rapid eye movements in Parkinson's disease. Nevrologicheskii zhurnal. 2015;(6);28-34. (In Russ.)].

6. Comella C. Sleep disorders in Parkinsons disease: an overview. Mov Disord. 2007 Sep;22 Suppl 17:S367-73. doi: 10.1002/mds.21682.

7. De Cock VC. Objective measures of the sleep-wake cycle in Parkinsons disease. In: Videnovic A, Hogl B, editors. Disorders of sleep and circadian rhythms in Parkinson's disease. Springer; 2015. P. 51-60.

8. Амосова НА, Смоленцева ИГ, Гусейнова ПМ и др. Нарушения сна на ранней стадии болезни Паркинсона у пациентов, не принимающих противопаркинсонические препараты. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(6):77-81. [Amosova NA, Smolentseva IG, Guseinova PM, et al. Sleep disorders at an early stage of Parkinson's disease in patients, who don’t take antiparkinsonian drugs. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(6): 77-81. (In Russ.)].

9. Postuma RB, Gagnon JF, Vendette M, et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology. 2009 Apr 14;72(15):1296-300. doi: 10.1212/01.wnl.0000340980.19702.6e. Epub 2008 Dec 24.

10. Sohail S, Yu L, Schneider JA, et al. Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. Mov Disord. 2017 Oct 30. doi: 10.1002/mds.27200. [Epub ahead of print]

11. Нодель МР, Ковров ГВ, Шевцова КВ и др. Клинико-электрофизиологические характеристики дневной сонливости при болезни Паркинсона. В кн.: Иллариошкин СН, Левин ОС, редакторы. Болезнь Паркинсона и расстройства движений. Руководство для врачей по материалам IV Национального конгресса по болезни Паркинсона и расстройствам движений (с международным участием). Москва; 2017. С. 136-9. [Nodel' MR, Kovrov GV, Shevtsova KV, et al. Clinical and electrophysiological characteristics of daytime sleepiness in Parkinson's disease. In: Illarioshkin SN, Levin OS, editors. Bolezn' Parkinsona i rasstroistva dvizhenii. Rukovodstvo dlya vrachei po materialam IV Natsional'nogo kongressa po bolezni Parkinsona i rasstroistvam dvizhenii (s mezhdunarodnym uchastiem) [Parkinson's disease and disorders of movement. Guidance for doctors on the materials of IV National Congress on Parkinson's disease and movement disorders (with international participation)]. Moscow; 2017. P. 136-9.]

12. Нодель МР. Утомляемость при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С. Корсакова. 2009;(9):23-6. [Nodel' MR. Fatigue in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2009;(9):23-6. (In Russ.)].

13. Литвиненко ИВ, Красаков ИВ, Тихомирова ОВ. Нарушения сна у больных с деменцией при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С. Корсакова 2011;111(9):37-42. [Litvinenko IV, Krasakov IV, Tikhomirova OV. Sleep disorders in patients with dementia in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2011;111(9):37-42. (In Russ.)].

14. Stavitsky K, Neargarder S, Bogdanova Y, et al. The impact of sleep quality on cognitive functioning in Parkinson's disease. J Int Neuropsychol Soc. 2012 Jan;18(1):108-17. doi: 10.1017/S1355617711001482.

15. Gallanger DA, Lees AJ, Shrag A. What are the most important nonmotor symptoms in patients with Parkinson’s disease and are we missing them? Mov Disord. 2010 Nov 15;25(15): 2493-500. doi: 10.1002/mds.23394.

16. Нодель МР. Влияние нервно-психических нарушений на качество жизни пациентов с болезнью Паркинсона. Неврологический журнал. 2015;(1):20-5. [Nodel' MR. The impact of neuropsychiatric symptoms on quality of life of patients with Parkinson's disease. Nevrologicheskii zhurnal. 2015;(1):20-5. (In Russ.)].

17. Chaudhuri KR, Prieto-Jurcynska C, Naidu Y, et al. The nondeclaration of nonmotor symptoms of Parkinson's disease to health care professionals: an international study using the nonmotor symptoms questionnaire. Mov Disord. 2010 Apr 30;25(6):704-9. doi: 10.1002/mds.22868.

18. Saper CB, Lu J, Chou TC, et al. The hypothalamic integrator for circadian rhythms. Trends Neurosci. 2005 Mar;28(3):152-7.

19. Ковальзон ВМ. Системные механизмы «бодрствования-сна». В кн. Основы сомнологии. Москва: Бином; 2011. C. 69-88. [Koval'zon VM. System mechanisms «wakefulness- sleep». In: Osnovy somnologii [Fundamentals of sleep medicine]. Moscow: Binom; 2011. P. 69-88.].

20. Ковальзон ВМ, Завалко ИМ. Нейрохимия цикла бодрствование-сон и болезнь Паркинсона. Нейрохимия. 2013;(3):193-206. [Koval'zon VM, Zavalko IM. Neurochemistry of the cycle sleep-wakefulness and Parkinson's disease. Neirokhimiya. 2013;(3):193-206. (In Russ.)].

21. Украинцева ЮВ, Ковальзон ВМ. Циркадианная регуляция и ее расстройства у пациентов с болезнью Паркинсона. Роль дофамина в циркадианной дисфункции. Физиология человека. 2016;(4):110–9. [Ukraintseva YuV, Koval'zon VM. Circadian regulation and its disorders in patients with Parkinson's disease. The role of dopamine in circadian dysfunction. Fiziologiya cheloveka. 2016;(4):110–9. (In Russ.)].

22. Bordet R, Devos D, Brique S, et al. Study of circadian melatonin secretion pattern at different stages of Parkinson’s disease. Clin Neuropharmacol. 2003 Mar-Apr;26(2):65-72.

23. Breen DP, Vuono R, Nawarathna U, et al. Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol. 2014 May;71(5): 589-595. doi: 10.1001/jamaneurol.2014.65.

24. Breen DP, Nombela C, Vuono R, et al. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease. Mov Disord. 2016 Jul;31(7):1062-6. doi: 10.1002/mds.26592. Epub 2016 Mar 12.

25. Bolitho SJ, Naismith SL, Rajaratnam SM, et al. Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med. 2014 Mar;15(3):342-7. doi: 10.1016/j.sleep.2013.10.016. Epub 2014 Jan 21.

26. Нодель МР, Русакова ИМ, Яхно НН. Клиническая оценка нарушений сна и бодрствования при болезни Паркинсона. Неврологический журнал. 2010;(2):19-25. [Nodel' MR, Rusakova IM, Yakhno NN. Clinical assessment of disorders of sleep and wakefulness in Parkinson's disease. Nevrologicheskii zhurnal. 2010;(2):19-25. (In Russ.)].

27. Кулуа ТК, Фёдорова НВ. Ночные нарушения при болезни Паркинсона и подходы к их коррекции. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;(12):63-6. [Kulua TK, Fedorova NV. Nochnye narusheniya pri bolezni Parkinsona i podkhody k ikh korrektsii. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;(12):63-6. (In Russ.)].

28. Нодель МР, Украинцева ЮВ, Яхно НН. Синдром нарушения поведения в фазе сна с быстрыми движениями глаз и никтурия при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;(9): 15-20. [Nodel' MR, Ukraintseva YuV, Yakhno NN. Syndrome of behavioral disturbances in the sleep phase with rapid eye movements and nocturia in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017; (9):15-20. (In Russ.)].

29. Chaudhuri KR, Pal S, DiMarco A, et.al. The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):629-35.

30. Postuma RB, Arnulf I, Hogl B, et al. A Single-Question Screen for rapid eye movement sleep behavior disorder: A Multicenter Validation Study. Mov Disord. 2012 Jun;27(7): 913-6. doi: 10.1002/mds.25037. Epub 2012 May 30.

31. Ferreiraa JJ, Katzenschlagerb R, Bloemc BR, et al. Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson’s disease. Eur J Neurol. 2013 Jan;20(1):5-15. doi: 10.1111/j.1468-1331.2012.03866.x.

32. Seppi K, Weintraub D, Coelho M, et al. The Movement Disorder Society evidencebased medicine review update: treatment for the non-motor symptoms in Parkinson's disease. Mov Disord. 2011 Oct;26 Suppl 3:S42-80. doi: 10.1002/mds.23884.

33. Videnovic A. Management of Sleep Disorders in Parkinsons Disease and multiple system atrophy. Mov Disord. 2017 May;32(5): 659-668. doi: 10.1002/mds.26918. Epub 2017 Jan 24.

34. Chaudhuri КR, Schapira AH. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009 May;8(5):464-74. doi: 10.1016/S1474-4422(09)70068-7.

35. Chahine LM, Daley J, Horn S, et al. Association between dopaminergic medications and nocturnal sleep in early-stage Parkinson's disease. Parkinsonism Relat Disord. 2013 Mar;19(3):359-62. doi: 10.1016/j.parkreldis. 2012.09.015. Epub 2012 Oct 23.

36. Chaudhuri KR, Martinez-Martin P, Rolfe KA, et al. Improvements in nocturnal symptoms with ropinirole prolonged release in patients with advanced Parkinson's disease. Eur J Neurol. 2012 Jan;19(1):105-13. doi: 10.1111/j.1468-1331.2011.03442.x. Epub 2011 Jun 23.

37. Dusek P, Buskova J, Ruzicka E, et al. Effects of ropinirole prolonged-release on sleep disturbances and daytime sleepiness in Parkinson disease. Clin Neuropharmacol. 2010 Jul;33(4): 186-90. doi: 10.1097/WNF.0b013e3181e71166.

38. Reichmann H, Cooper J, Rolfe K, Martinez-Martin P. Sleep Duration and «on» Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release. Parkinsons Dis. 2011;2011: 354760. doi: 10.4061/2011/354760. Epub 2011 May 11.

39. Gjerstad MD, Alves G, Wentzel-Larsen T, et al. Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology. 2006 Sep 12;67(5):853-8.

40. Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, et al. Effect of exogenous melatonin on sleep and motor dysfunction in PD. A randomized, double blind, placebo controlled study. J Neurol. 2007 Apr;254(4):459-64. Epub 2007 Apr 3.

41. Нодель МР. Современные возможности терапии нарушений сна у пациентов с болезнью Паркинсона. Неврология, нейропсихиатрия, психосоматика. 2013;5(2):29-34. [Nodel' MR. Current possibilities of therapy for sleep disorders in Parkinson’s disease. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2013;5(2): 29-34. (In Russ.)]. doi: 10.14412/2074-2711-2013-2409

42. Ковров ГВ, Любшина ОВ. Современные тенденции в диагностике и лечении инсомний. Русский медицинский журнал. 2007;(4):202–5. [Kovrov GV, Lyubshina OV. Current trends in the diagnosis and treatment of insomnia. Russkii meditsinskii zhurnal. 2007;(4): 202–5. (In Russ.)].

43. Морозова ЛГ, Посохов СИ, Ковров ГВ. Особенности субъективной оценки при нарушении качества сна и бодрствования у больных с психофизической инсомнией. Неврологический журнал. 2011;(5):30-4. [Morozova LG, Posokhov SI, Kovrov GV. Features of subjective evaluation for violation of quality of sleep and wakefulness in patients with psychophysical insomnia. Nevrologicheskii zhurnal. 2011;(5):30-4. (In Russ.)].

44. Rios Romenets S, Creti L, Fichten C, et al. Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease – a randomized study. Parkinsonism Relat Disord. 2013 Jul;19(7):670-5. doi: 10.1016/j.parkreldis.

45. Yang H, Petrini M. Effect of cognitive behavior therapy on sleep disorder in Parkinson's disease in China: a pilot study. Nurs Health Sci. 2012 Dec;14(4):458-63. doi: 10.1111/j.1442-2018.2012.00711.x.

46. Nascimento CM, Ayan C, Cancela JM, et al. Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients. Geriatr Gerontol Int. 2014 Apr;14(2):259-66. doi: 10.1111/ggi.12082. Epub 2013 May 6.


For citation:


Nodel M.R., Kovrov G.V. Sleep disorders in Parkinson’s disease: approaches to treatment and prevention. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):88-94. (In Russ.) https://doi.org/10.14412/2074-2711-2017-4-88-84

Views: 545


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)