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USE OF DIMETHYL FUMARATE IN THE TREATMENT OF MULTIPLE SCLEROSIS: CLINICAL AND ECONOMIC ANALYSIS

https://doi.org/10.14412/2074-2711-2016-4-98-103

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Abstract

The paper presents a review of an update on the comparative pharmacoeconomic analysis of using dimethyl fumarate in the treatment of multiple sclerosis (MS) in European countries. A pharmacoeconomic evaluation was made to study the use of first-line oral dimethyl fumarate versus another first-line oral teriflunomide in the treatment of MS in the Russian Federation (for 1 year) and second-line natalizumab and fingolimod. Among first-line oral drugs, dimethyl fumarate was shown to be superior to teriflunomide in a cost-effectiveness ratio and to be slightly ahead of the MS-modifying drugs (MSMDs)  and the second-line drugs natalizumab and fingolimod. According to clinical and economic indicators, dimethyl fumarate is the drug of choise among other MSMDs in the treatment of MS.

About the Authors

V. R. Mkrtchyan
Z.P. Solovyev Research and Practical Psychoneurology Center, Moscow Healthcare Department
Russian Federation

Violetta Rafaelyevna Mkrtchyan.

43, Donskaya St., Moscow 115419,  vrm1958@gmail.com



L. V. Brylev
Z.P. Solovyev Research and Practical Psychoneurology Center, Moscow Healthcare Department; V.M. Buyanov City Clinical Hospital
Russian Federation

43, Donskaya St., Moscow 115419; 26, Bakinskaya St., Moscow 115516



I. A. Shpak
Z.P. Solovyev Research and Practical Psychoneurology Center, Moscow Healthcare Department
Russian Federation

43, Donskaya St., Moscow 115419



A. M. Sergeev
Institute of Applied Economic Researches, Russian Presidential Academy of National Economy and Public Administration
Russian Federation

84, Vernadsky Prospect, Moscow 119606



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For citation:


Mkrtchyan V.R., Brylev L.V., Shpak I.A., Sergeev A.M. USE OF DIMETHYL FUMARATE IN THE TREATMENT OF MULTIPLE SCLEROSIS: CLINICAL AND ECONOMIC ANALYSIS. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(4):98-103. (In Russ.) https://doi.org/10.14412/2074-2711-2016-4-98-103

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)