HYPERSOMNIA AND CIRCADIAN DISTURBANCES IN PARKINSON’S DISEASE
https://doi.org/10.14412/2074-2711-2016-4-45-50
Abstract
Excessive daytime sleepiness (hypersomnia) is one of the clinically important, but inadequately studied symptoms of Parkinson’s disease (PD). It manifests as constant excessive sleepiness during the day and/or short unexpected (unintentional) naps. Hypersomnia negatively affects quality of life in patients; it is potentially dangerous in the situations requiring greater attention. The paper presents current approaches to diagnosing hypersomnia in PD. It discusses the multifactorial nature of its pathophysiology in patients with PD. The present-day ideas about the relationship of hypersomnia to degeneration of the brain structures involved in the regulation of sleep and wakefulness, to nocturnal sleep disorders and dopaminergic therapy are described. The paper gives the results of experimental and clinical studies confirming the role of circadian mechanisms in the manifestation of insomnia and hypersomnia in PD patients. It describes a clinical case of a patient with moderate motor and cognitive impairments, in whom hypersomnia is a leading factor in deteriorating daily life. The possible role of circadian disturbances in the development of hypersomnia and related mild manifestations of insomnia and parasomnia is discussed. A clinically significant effect in treating sleep and wakefulness disorders has been achieved in the prolonged use of melatonin and cognitive-behavioral therapy.
About the Author
M. R. Nodel
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Marina Romanovna Nodel - Department of Nervous System Diseases and Neurosurgery.
11, Rossolimo St., Moscow 119021, nodell_m@yahoo.com
References
1. Battista J, Monderer R, Thory M. Excessive Daytime Somnolence associated with Parkinsons Disease.In : disorders of sleep and circadian rhythms. In: Videnovich A, Hogl B, editors. Parkinsons Disease. Wien: Springer-Verlag; 2015. P. 107-16.
2. De Cock VC, Vidailhet M, Arnulf I. Sleep disturbances in patients with parkinsonism. Nat Clin Pract Neurol. 2008 May;4(5):254-66. doi: 10.1038/ncpneuro0775. Epub 2008 Apr 8.
3. Arnulf I, Konofal E, Merino-Andreu M, et al. Parkinson's disease and sleepiness: an integral part of PD. Neurology. 2002 Apr 9;58(7):1019-24.
4. Abbott R, Ross G. White L. Excessive daytime sleepiness and subsequent development of Parkinson Disease. Neurology. 2005 Nov 8; 65(9):1442-6.
5. Spindler M, Gooneratne NS, Siderowf A, et al. Daytime sleepiness is associated with falls in Parkinsons disease. J Parkinsons Dis. 2013 Jan 1;3(3):387-91. doi: 10.3233/JPD-130184.
6. Литвиненко ИВ, Красаков ИВ, Тихомирова ОВ. Нарушения сна у больных с деменцией при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С.Корсакова. 2011;111(9):37-42. [Litvinenko IV, Krasakov IV, Tikhomirova OV. Sleep disturbances in patients with dementia in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;111(9):37-42. (In Russ.)].
7. Gjerstad M, Wentzel-Larsen T, Aarsland D, et al. Insomnia in Parkinsons Disease : frequency and progression over time. J Neurol Neurosurg Psychiatry. 2007 May;78(5):476-9. Epub 2006 Nov 10.
8. Gallagher DA, Lees AJ, Shrag A. What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? Mov Disord. 2010 Nov 15; 25(15):2493-500. doi: 10.1002/mds.23394.
9. Нодель МР. Влияние нервно-психических нарушений на качество жизни пациентов с болезнью Паркинсона. Неврологический журнал. 2015;(1):20-5. [Nodel' MR. The impact of neuropsychiatric symptoms on quality of life of patients with Parkinson's disease. Nevrologicheskii zhurnal. 2015;(1):20-5. (in Russ.)].
10. Suzuki K, Miyamoto T, Miyamoto M, et. al. Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease. J Neurol Sci. 2008 Aug 15;271(1-2):47-52. doi: 10.1016/j.jns.2008.03.008. Epub 2008 Apr 23.
11. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5.
12. Merino-Andrew M, Arnulf I, Konofal E. Unawareness of naps in Parkinson's disease and in disorders with excessive daytime sleepiness. Neurology. 2003 May 13;60(9):1553-4.
13. Littner MR, Kushida C, Wise M. Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep. 2005 Jan; 28(1):113-21.
14. Ковальзон ВМ. Системные механизмы «бодрствования-сна». В кн.: Основы сомнологии. Москва: Бином; 2011. С. 69-88. [Koval'zon VM. System mechanisms of «wakefulness-sleep». In: Osnovy somnologii [Fundamentals of sleep medicine]. Moscow: Binom; 2011. P. 69-88.]
15. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease. Brain. 2007 Jun;130(Pt 6):1586-95. Epub 2007 May 9.
16. Бабкина ОВ, Полуэктов МГ, Левин ОС. Гетерогенность дневной сонливости при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С.Корсакова. 2016;111:(6):60-70. [Babkina OV, Poluektov MG, Levin OS. The heterogeneity of daytime sleepiness in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. S.S.Korsakova. 2016;111:(6): 60-70. (In Russ.)].
17. Stevens S, Comella CL, Stepanski EJ. Daytime sleepiness and alertness in patients with Parkinsons disease. Sleep. 2004 Aug 1;27(5):967-72.
18. Rye DB. Excessive daytime sleepiness and unintended sleep in Parkinsons disease. Curr Neurol Neurosci Rep. 2006 Mar;6(2):169-76.
19. Нодель МР, Яхно НН, Украинцева ЮВ. Гиперсомния при болезни Паркинсона. Неврологический журнал. 2014;19(6):9-16. [Nodel' MR, Yakhno NN, Ukraintseva YuV. Hypersomnia in Parkinson's disease. Nevrologicheskii zhurnal. 2014;19(6):9-16. (In Russ.)].
20. Нодель МР, Украинцева ЮВ, Яхно НН. Синдром нарушения поведения в фазе сна с быстрыми движениями глаз при болезни Паркинсона. Неврологический журнал. 2015;20(6):28-34. [Nodel' MR, Ukraintseva YuV, Yakhno NN. Syndrome of behavioral disturbances in the sleep phase with rapid eye movements in Parkinson's disease. Nevrologicheskii zhurnal. 2015;20(6):28-34. (In Russ.)].
21. Ferreira JJ, Katzenschlager R, Bloem BR, et al. Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson's disease. Eur J Neurol. 2013 Jan;20(1):5-15. doi: 10.1111/j.1468-1331.2012.03866.x.
22. Paus S, Brecht HM, Kö ster J. Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson's disease. Mov Disord. 2003 Jun; 18(6):659-67.
23. Katsuki H, Michinaga S. Anti-Parkinson Drugs and Orexin Neurons. Vitam Horm. 2012;89:279-90. doi: 10.1016/B978-0-12-394623-2.00015-9.
24. Украинцева ЮВ, Ковальзон ВМ. Циркадианная регуляция и ее расстройства у пациентов с болезнью Паркинсона. Часть 1. Роль дофамина в циркадианной дисфункции. Физиология человека. 2016;42(4):110–9. [Ukraintseva YuV, Koval'zon VM. Circadian regulation and its disorders in patients with Parkinson's disease. Part 1. The role of dopamine in circadian dysfunction. Fiziologiya cheloveka. 2016;42(4):110–9. (in Russ.)].
25. Gravotta L, Gavrila AM, Hood S, et al. Global depletion of dopamine using intracerebroventricular 6-hydroxydopamine injection disrupts normal circadian wheel-running patterns and PERIOD2 expression in the rat forebrain. J Mol Neurosci. 2011 Oct;45(2): 162-71. doi: 10.1007/s12031-011-9520-8. Epub 2011 Apr 12.
26. Archibald NK, Clarke MP, Mosimann UP, et al. The retina in Parkinson's disease. Brain. 2009 May;132(Pt 5):1128-45. doi: 10.1093/brain/awp068. Epub 2009 Mar 31.
27. Politis M, Piccini P, Pavese N, et al. Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson's disease: an in vivo 11C-raclopride PET study. Exp Neurol. 2008 Nov;214(1):112-6. doi: 10.1016/j.expneurol.2008.07.021. Epub 2008 Aug 6.
28. Adi N, Mash DC, Ali E, et al. Melatonin MT1 and MT2 receptors expression in Parkinsons disease. Med Sci Monit. 2010 Feb; 16(2):BR61-7.
29. Bordet R, Devos D, Brique S, et al. Study of circadian melatonin secretion pattern at different stages of Parkinson's disease. Clin Neuropharmacol. 2003 Mar-Apr;26(2):65-72.
30. Videnovic A, Noble C, Reid KJ, et al. Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol. 2014 Apr;71(4):463-9. doi: 10.1001/jamaneurol.2013.6239.
31. Breen DP, Vuono R, Nawarathna U, et al. Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol. 2014 May; 71(5):589-95. doi: 10.1001/jamaneurol.2014.65.
32. Breen DP, Nombela C, Vuono R, et.al. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease. Mov Disord. 2016 Jul;31(7):1062-6. doi: 10.1002/mds.26592. Epub 2016 Mar 12.
33. Bolitho SJ, Naismith SL, Rajaratnam SM, et al. Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med. 2014 Mar;15(3):342-7. doi: 10.1016/j.sleep.2013.10.016. Epub 2014 Jan 21.
34. Fertl E, Auff E, Doppelbauer A, Waldhauser F. Circadian secretion pattern of melatonin in de novo parkinsonian patients: evidence for phaseshifting properties of L-dopa. J Neural Transm Park Dis Dement Sect. 1993;5(3):227-34.
35. Lin L, Du Y, Yuan S, et al. Serum melatonin is an alternative index of Parkinson's disease severity. Brain Res. 2014 Feb 14;1547: 43-8. doi: 10.1016/j.brainres.2013.12.021. Epub 2013 Dec 30.
36. Kim JS, Bailey MJ, Weller JL, et al. Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4). Mol Cell Endocrinol. 2010 Jan 15;314(1):128-35. doi: 10.1016/j.mce. 2009.05.013. Epub 2009 May 29.
37. Dowling G, Mastick J, Colling E, et al. Melatonin for sleep disturbances in PD. Sleep Med. 2005 Sep;6(5):459-66.
38. Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, et al. Effect of exogenous melatonin on sleep and motor dysfunction in PD. A randomized, double blind, placebo controlled study. J Neurol. 2007 Apr;254(4):459-64. Epub 2007 Apr 3.
39. Wurts SW, Edgar DM. Circadian and homeostatic control of rapid eye movement (REM) sleep: promotion of REM tendency by the suprachiasmatic nucleus. J Neurosci. 2000 Jun 1;20(11):4300-10.
40. Zhong G, Bolitho S, Grunstein R, et al. The relationship between thermoregulation and REM sleep behaviour disorder in Parkinson's disease. PLoS One. 2013 Aug 21;8(8):e72661. doi: 10.1371/journal.pone.0072661.eCollection 2013.
41. Kunz D, Mahlberg R. A two-part, doubleblind, placebo-controlled trial of exogenous melatonin in REM sleep behavior disorder. J Sleep Res. 2010 Dec;19(4):591-6. doi: 10.1111/j.1365-2869.2010.00848.x.
42. Lyseng-Williamson KA. Melatonin prolonged release: a guide to its use in the treatment of insomnia in patients aged ≥55 years. Drugs & Therapy Perspectives. 2013;29(5):125-9.
43. Ковров ГВ, Агальцов МВ, Cукмарова ЗН. Эффективность мелатонина пролонгированного высвобождения при первичных нарушениях сна у пациентов старше 55 лет. Неврология, нейропсихиатрия, психососматика. 2016;8(2):24-30. [Kovrov GV, Agal'tsov MV, Cukmarova ZN. Effectiveness of prolongedrelease melatonin in Improving Quality of Sleep in Patients Aged 55 or Over. Nevrologiya, neiropsikhiatriya, psikhososmatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2): 24-30. (in Russ.)]. DOI: 10.14412/2074-2711-2016-2-24-30
44. Wilson SJ, Nutt DJ, Alford C. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol. 2010 Jun;24(6): 915-21. doi: 10.1177/0269881108100093. Epub 2009 Jan 22.
45. Morin CM, Bootzin RR, Buysse DJ, et al. Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004). Sleep. 2006 Nov;29(11):1398-414.
Review
For citations:
Nodel MR. HYPERSOMNIA AND CIRCADIAN DISTURBANCES IN PARKINSON’S DISEASE. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(4):45-50. (In Russ.) https://doi.org/10.14412/2074-2711-2016-4-45-50
Views:
1380
Email this article 